PMID: 8599850Feb 1, 1995Paper

Dendritic resident cells and their immunohistologic determination

Ceskoslovenská patologie
B Bednár

Abstract

Resident dendritic cells exist in various tissues. They belong to RES according to determining marks and their transitions. The main marks represent phagocytosis, fixed and mobile scavenging, endothelial and stroma-parenchyma barrier function and collagens production. Suppression of some extreme marks stimulates prevalence of remaining marks. An interesting topic concerns immune engaged dendritic cells. Their main mark is inability of transporting antigens and of presenting them to lymphatic tissue so that they start an immune reaction. Differences among dendritic cells can be detected by immunohistology. Immunopositivity of resident dendritic cells was studied in 20 tissues (lymphatic, skin, bone, soft, nervous, myocardial, lung, oesophagus, stomach, intestinal and others) by using antibodies: CD 34, F XIIIa, F VIII, actin, CD 68, S-100 protein, HLA-DR, CD3, and OPD4. Because a simple comparison of detected immunophenotypes was often ambiguous, positivity of dendritic cells was compared with positivity level of neighbouring tissues in 16 cases. Nevertheless, any single marker was not relevant in all cases. But decisive positive combinations did exist (CD 34 for non-X cells, CD 68 for phagocytes, S-100 for X cells). Dendritic c...Continue Reading

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