Oct 26, 2018

Dendritic spikes expand the range of well-tolerated population noise structures

BioRxiv : the Preprint Server for Biology
Alon Poleg-Polsky


The brain operates surprisingly well despite the noisy nature of individual neurons. The central mechanism for noise mitigation in the nervous system is thought to involve averaging over multiple noise-corrupted inputs. Subsequently, there has been considerable interest recently to identify noise structures that can be integrated linearly in a way that preserves reliable signal encoding. By analyzing realistic synaptic integration in biophysically accurate neuronal models, I report a complementary de-noising approach that is mediated by focal dendritic spikes. Dendritic spikes might seem to be unlikely candidates for noise reduction due to their miniscule integration compartments and poor averaging abilities. Nonetheless, the extra thresholding step introduced by dendritic spike generation increases neuronal performance for a broad category of computational tasks, including analog and binary discrimination, as well as for a range of correlated and uncorrelated noise structures, some of which cannot be adequately resolved with averaging. This property of active dendrites compensates for compartment size constraints and expands the repertoire of brain states and presynaptic population activity dynamics can be reliably de-noised b...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Dendrite of Motor Neuron
Presynaptic Terminals
Entire Nervous System
Nervous System Structure
Brain Function

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Network : Computation in Neural Systems
Adam Kepecs, John Lisman
IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Mehdi AghagolzadehKarim G Oweiss
Current Opinion in Neurobiology
Matthew E Larkum, Thomas Nevian
© 2020 Meta ULC. All rights reserved