Dendroarchitecture and lateral inhibition in thalamic barreloids

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Philippe Lavallée, M Deschênes

Abstract

Thalamic cells that relay vibrissa information to barrel cortex are clustered within whisker-related modules termed barreloids. Each barreloid receives input from one principal whisker and inhibitory inputs from reticular thalamic neurons with receptive fields that correspond to that same whisker. Although the proximal dendrites of relay cells are confined to their home barreloid, distal dendrites often extend into surrounding barreloids representing adjacent whiskers on the mystacial pad. It was proposed that this arrangement provides a substrate for a mechanism of lateral inhibition that operates remotely on extrabarreloid dendrites. In the present study, we identified adjacent whiskers that suppressed activity below background levels in barreloid cells, and we used a double-labeling protocol to relate the efficacy of inhibition to the dendroarchitecture of the cells. Significant suppression of background discharges was produced by 92% of adjacent whiskers within rows, by 48% of adjacent whiskers within arcs, but was never observed after deflection of nonadjacent whiskers. The magnitude of lateral inhibition increases linearly as the cumulated length of dendrites increases in the barreloid representing an adjacent whisker (R2...Continue Reading

Citations

Jan 29, 2010·PloS One·Stuart P WilsonJames A Bednar
Nov 19, 2011·PloS One·Fredrik LindstedtMartin Ingvar
Aug 3, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunyan WangJosé L Peña
Oct 9, 2008·Neuroscience·C Kopp-ScheinpflugR Rübsamen
Jun 5, 2007·Trends in Neurosciences·John R Huguenard, David A McCormick
Nov 24, 2004·Progress in Neurobiology·Manuel A Castro-Alamancos
Aug 5, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Guy Doron, Michael Brecht
Oct 18, 2005·Progress in Brain Research·Martin DeschênesCaroline Dufresne
May 2, 2009·Journal of Communication Disorders·Meredith E Estep
Dec 4, 2009·Journal of Neurophysiology·Arthur R HouwelingMichael Brecht
Aug 15, 2019·Journal of Neurophysiology·Valerie Ego-StengelDaniel E Shulz
Oct 11, 2017·Brain Structure & Function·Daichi HiraiTakahiro Furuta
Sep 10, 2019·Frontiers in Systems Neuroscience·Mehdi Adibi
Mar 6, 2021·PeerJ·Thomas F Burns, Ramesh Rajan

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