Dendrobine, an antagonist of beta-alanine, taurine and of presynaptic inhibition in the frog spinal cord

British Journal of Pharmacology
Y KudoK Yamada

Abstract

1 The effects of dendrobine and nobiline, alkaloids isolated from Dendrobium nobile, on the electrical activity and on amino acid-induced depolarizations of primary afferent terminals were tested on the frog isolated spinal cord and were compared with those of picrotoxinin and strychnine. 2 Dendrobine (3 X 10(-5) M) caused a slight hyperpolarization in both dorsal and ventral roots and this hyperpolarization was accompanied by the augmentation of the dorsal root potential (DR-DRP) and the ventral root potential and reflex (DR-VRP and DR-VRR). The amplitude of the dorsal root reflex (DR-DRR) however, was reduced significantly. Nobiline (3 X 10(-5) M) had no significant effect on either the root potentials or the reflexes. 3 Dendrobine (3 X 10(-5) M) reduced the dorsal root potential induced by repetitive antidromic stimulation of ventral root (VR-DRP) as well as diminishing the maximum rate of rise of the dorsal root potential induced by the stimulation of adjacent dorsal roots (DR-DRP), during which time the amplitude of the DR-DRP was seen to be augmented. 4 Dendrobine (3 X 10(-5) M) reduced the beta-alanine- and taurine-induced depolarizations of primary afferent terminals, while having little effect upon GABA- and glycine-in...Continue Reading

References

Mar 1, 1975·The Journal of Physiology·J L BarkerA Padjen
Jan 1, 1978·Progress in Neurobiology·Y Kudo
Jun 1, 1975·European Journal of Pharmacology·Y KudoH Fukuda
Jan 1, 1968·Pflügers Archiv : European journal of physiology·K C Holemans, H S Meij
Jul 1, 1968·Journal of Medicinal Chemistry·C H JarboeR T Buckler
Mar 1, 1969·Comparative Biochemistry and Physiology·A K Tebecis, J W Phillis
Dec 1, 1963·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y INUBUSHIJ NAKANO
Apr 1, 1964·Chemical & Pharmaceutical Bulletin·T ONAKAM SHIMIZU

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Citations

Jan 1, 1989·Progress in Neurobiology·R J Huxtable
Jan 1, 1997·Pharmacology & Therapeutics·S RajendraP R Schofield
May 23, 2013·Food Chemistry·Massimo MorettiMaria Carla Marcotullio
Jul 24, 2013·Critical Reviews in Toxicology·M Helena R AmorimMargarida M S M Bastos
Apr 19, 2017·Journal of Agricultural and Food Chemistry·Richan LiJie Yang
Apr 1, 1988·Medicinal Research Reviews·Y BanN Takano
Oct 30, 2012·Molecular Biology Reports·Wei ChenHuizhong Wang

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