Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Lin XiaoKalin Yanbo Zhang

Abstract

This study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms.

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Citations

Dec 26, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L XiangY B Kalin Zhang
Feb 11, 2012·Applied Microbiology and Biotechnology·Tzi Bun NgKalin Yanbo Zhang
Aug 19, 2011·International Immunology·Xiang LinKalin Yanbo Zhang
Mar 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chu ChuLin Zhu
Jul 30, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jingjing FanWenyuan Liu
May 7, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yau LamKalin Yanbo Zhang
Jan 19, 2018·Aging and Disease·Veronika CakovaAnnelise Lobstein
Feb 16, 2017·Applied Microbiology and Biotechnology·Jaime A Teixeira da Silva, Tzi Bun Ng
Mar 6, 2021·Journal of Food Biochemistry·Xiong-Zhang YinCheng-Bin Xue
Apr 13, 2021·Journal of Dental Research·S M LeeD Y Kim
Jul 31, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Reza Rastmanesh

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