PMID: 8458063Feb 1, 1993Paper

Dendrotoxin blocks a class of potassium channels that are opened by inhibitory presynaptic modulators in rat cortical synaptosomes and slices

Cellular and Molecular Neurobiology
G Zoltay, J R Cooper

Abstract

1. Rat cortical synaptosomes were prelabeled with radioactive acetylcholine and the release induced by veratridine was determined in the absence and presence of the inhibitory presynaptic modulators, 2-chloroadenosine, carbamylcholine, clonidine, and morphine. All four agents inhibited the evoked release of acetylcholine and this inhibition was reversed by dendrotoxin. 2. Using perfused cortical slices and an extracellular K-sensitive electrode, all modulators again increased K efflux that was blocked by dendrotoxin. In contrast, glybenclamide and tetraethylammonium did not block the modulator-induced efflux.

References

Jan 9, 1992·Biochemical Pharmacology·J K Aronson
Sep 1, 1990·Journal of Neurochemistry·G Zoltay, J R Cooper
Aug 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·U WellerE Habermann
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J V HalliwellJ O Dolly
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