Denervation and hyperinnervation in the nervous system of diabetic animals. II. Monoaminergic and peptidergic alterations in the diabetic encephalopathy.

Journal of Neuroscience Research
A M Di GiulioA Gorio

Abstract

The monoaminergic innervation of the central nervous system (CNS) is characterized by long and short projecting neurons. The neurological correlates of diabetes are usually referred to as processes of degenerative atrophy affecting motor and sensory peripheral nerves. We have found that the long serotoninergic axons innervating the spinal cord and the cerebral cortex are unaffected in diabetic animals and that the noradrenergic innervation of the cortex is normal as well. The serotonin content is doubled in the hypothalamus with no apparent alteration of 5-HIAA levels, suggesting a supernumerary innervation that is accompanied by a reduced release. In pons medulla oblongata, serotonin and dopamine with the relative metabolites 5-HIAA and DOPAC are significantly reduced, whereas noradrenaline is markedly increased. In the hippocampus, there is a reduction of serotonin content. The serotoninergic alterations are peculiar as suggested by the sparing of the most distal projections that is accompanied by hyperinnervation of the hypothalamus and the loss of shorter collaterals in the pons medulla oblongata. In the hypothalamus and in the striatum of diabetic rats, there are significant higher levels of substance P and met-enkephalin,...Continue Reading

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Citations

Oct 1, 1995·Diabetes/metabolism Reviews·U Di MarioG Pozzessere
Nov 1, 1995·Journal of Neuroscience Research·A M Di GiulioA Gorio
Dec 15, 1995·Journal of Neuroscience Research·E GermaniA Gorio
Jul 1, 1994·Diabetologia·G J BiesselsW H Gispen
May 6, 1996·European Journal of Pharmacology·A GorioA M Di Giulio
Feb 17, 1995·Neuroscience Letters·R Ramakrishnan, A Namasivayam
Jul 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A GorioA M Di Giulio
Oct 30, 2012·American Journal of Respiratory Cell and Molecular Biology·Gregory D ScottDavid B Jacoby
Nov 1, 1993·Metabolism: Clinical and Experimental·J S Kumar, V P Menon
Oct 10, 2013·Autonomic Neuroscience : Basic & Clinical·Robert J PhillipsTerry L Powley
May 27, 1999·Molecular and Chemical Neuropathology·G Kaur, S K Bhardwaj

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