PMID: 2097582Oct 30, 1990Paper

Denervation-induced inflammation in the rat

Neuroscience Letters
J D LevineA I Basbaum

Abstract

We report that section of the sciatic and saphenous nerves, in the hindlimb of the rat, evokes an inflammatory response in the denervated tissue that can be distinguished from the previously described peptide-mediated neurogenic inflammation. This novel form of neurogenic inflammation has a very delayed onset (9.75 +/- 2.1 h, mean +/- S.E.M., n = 8), persists for more than 30 h, and is characterized by a marked neutrophilic cellular infiltrate. These features cannot be mimicked by electrical stimulation of the peripheral nerve and are not prevented by either prior application of local anesthetics to the nerve lesion site or by neonatal treatment with capsaicin.

References

Jan 1, 1978·Annual Review of Pharmacology and Toxicology·K Kristensson
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·N JancsóJ Szolcsányi

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Citations

Oct 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D J Tracey, J S Walker
Aug 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M BassiratZ Khalil
Dec 13, 2000·Neuroscience·N M Perkins, D J Tracey
Dec 1, 1999·Neuroscience·J P SyriatowiczD J Tracey
Jul 5, 2005·Nature Reviews. Neuroscience·Fabien MarchandStephen B McMahon

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