PMID: 8600761Mar 1, 1996Paper

Dengue encephalitis: a true entity?

The American Journal of Tropical Medicine and Hygiene
L C LumF Harun

Abstract

Involvement of the central nervous system in dengue fever and dengue hemorrhagic fever has always been thought to be secondary to vasculitis with resultant fluid extravasation, cerebral edema, hypoperfusion, hyponatremia, liver failure, and/or renal failure. Thus, the condition has been referred to as dengue encephalopathy. Encephalitis or direct involvement of the brain by the virus was thought to be unlikely. This paper reports on six children who were seen over a period of two years presenting on the second or third day of illness with dengue encephalitis. The diagnosis was based upon a clinical picture of encephalitis and confirmed by cerebrospinal fluid (CSF) microscopy and electroencephalography changes. All six cases were confirmed dengue infections. Dengue 3 virus was isolated from the CSF of four cases and in one case, dengue 2 was detected by the polymerase chain reaction in both the CSF and blood. In the sixth case, virologic evidence was negative but dengue immunoglobulin M was detected in the CSF and blood. Since the onset of encephalitis appears early in the course of illness coinciding with the viremic phase, we postulate that the virus crosses the blood-brain barrier and directly invades the brain causing enceph...Continue Reading

Citations

Nov 23, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R GallerM S Freire
Aug 21, 2007·Journal of Medical Virology·Juliano BordignonClaudia N Duarte Dos Santos
May 4, 2010·PLoS Neglected Tropical Diseases·Grace K TanSylvie Alonso
Jul 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Suchitra Ranjit, Niranjan Kissoon
Apr 23, 2011·The Journal of Biological Chemistry·Jeffrey E McLeanZahra Zakeri
Mar 13, 2013·The American Journal of Tropical Medicine and Hygiene·Jomil M Torres-AponteKay M Tomashek
Jul 6, 2014·Indian Pediatrics·Arti PawariaJagdish Meena
Apr 1, 2006·Continuum : Lifelong Learning in Neurology·May H HanJoseph R Zunt
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Deepak MadiSoundarya Mahalingam
Jul 29, 2015·Pediatric Radiology·Ruchi Rastogi, Bhavya Garg
Apr 16, 2019·Frontiers in Microbiology·Yasmin Mucunã MustafáLuciana Barros de Arruda
Sep 7, 2019·Journal of Medical Case Reports·W S Weerasinghe, Arjuna Medagama
Dec 10, 1999·Tropical Medicine & International Health : TM & IH·B MurgueC Roche
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·S K KabraV Seth
Aug 29, 2000·Journal of Child Neurology·P KankirawatanaV Pongthapisit
Aug 15, 2006·Tropical Medicine & International Health : TM & IH·Shibani BandyopadhyayAxel Kroeger
Aug 2, 2005·Arquivos de neuro-psiquiatria·Maria Lúcia Brito FerreiraSolange Dornelas Mesquita
Oct 19, 2005·Emerging Infectious Diseases·Rita Maria Ribeiro NogueiraMarize Pereira Miagostovich
Jan 6, 2005·The Neurologist·May H Han, Joseph R Zunt
Dec 16, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·G P MateuR Galler
Jul 20, 2010·Interdisciplinary Sciences, Computational Life Sciences·Pallavi SomvanshiP K Seth
Jul 25, 2012·Journal of Neurovirology·Myriam Lucia Velandia-RomeroJaime E Castellanos
Apr 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peng-Peng Ip, Fang Liao
Dec 30, 2011·The Neuroradiology Journal·R B KambleC N Raghunath
Jan 30, 2015·Emerging Infectious Diseases·Sonja J OlsenUNKNOWN Thailand Encephalitis Surveillance Team
May 5, 2017·PLoS Neglected Tropical Diseases·Deborah H L Ng, Sapna P Sadarangani
Feb 13, 2020·F1000Research·Rashmi Kumar
Apr 22, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mun-Yik FongSai-Kit Lam
Apr 16, 2003·Virchows Archiv : an International Journal of Pathology·Jing AnKotaro Yasui
Sep 3, 2010·The American Journal of Tropical Medicine and Hygiene·Stanley Almeida AraújoVandack Nobre
Jan 7, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Praveen Khilnani
Dec 7, 2010·Scandinavian Journal of Infectious Diseases·Moumita GhoshSwapna Chakraborty
Nov 6, 2014·The American Journal of Tropical Medicine and Hygiene·Stephen H WatermanJames J Sejvar
Jan 14, 2012·Journal of Tropical Pediatrics·Moumita SamantaSukanta Chatterjee
Feb 6, 2017·BMC Research Notes·Lavanya RajagopalaMadhava Karunarathna
Oct 5, 2018·PLoS Neglected Tropical Diseases·Kay M TomashekDuane J Gubler
Jul 12, 2019·Frontiers in Microbiology·María-Angélica Calderón-PeláezJaime E Castellanos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.