Dengue in Bali: Clinical characteristics and genetic diversity of circulating dengue viruses

PLoS Neglected Tropical Diseases
Dewi MegawatiR Tedjo Sasmono

Abstract

A high number of dengue cases are reported annually in Bali. Despite the endemicity, limited data on dengue is available for Bali localities. Molecular surveillance study was conducted to explore the clinical and virological characteristics of dengue patients in urban Denpasar and rural Gianyar areas in Bali during the peak season in 2015. A total of 205 adult dengue-suspected patients were recruited in a prospective cross-sectional study. Demographic and clinical information were obtained, and dengue screening was performed using NS1 and IgM/IgG ELISAs. Viral RNA was subsequently extracted from patients' sera for serotyping using conventional RT-PCR and Simplexa Dengue real-time RT-PCR, followed by genotyping with sequencing method. We confirmed 161 patients as having dengue by NS1 and RT-PCR. Among 154 samples successfully serotyped, the DENV-3 was predominant, followed by DENV-1, DENV-2, and DENV-4. Serotype predominance was different between Denpasar and Gianyar. Genotyping results classify DENV-1 isolates into Genotype I and DENV-2 as Cosmopolitan Genotype. The classification grouped isolates into Genotype I and II for DENV-3 and DENV-4, respectively. Clinical parameters showed no relationship between infecting serotypes a...Continue Reading

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Citations

Jun 29, 2018·PLoS Neglected Tropical Diseases·R Tedjo SasmonoJoshua Nealon
Jun 28, 2018·Memórias do Instituto Oswaldo Cruz·Marcos César Lima de MendonçaAna Maria Bispo de Filippis
Oct 22, 2019·PLoS Neglected Tropical Diseases·I Made Susila UtamaKetut Tuti Merati Parwati
Jul 3, 2020·Japanese Journal of Infectious Diseases·Beti Ernawati DewiFithriyah Sjatha
Jul 15, 2020·PLoS Neglected Tropical Diseases·Chairin Nisa Ma'roefKhin Saw Aye Myint
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Aug 20, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·R Tedjo SasmonoDionisius Denis
Sep 17, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Rahma F HayatiR Tedjo Sasmono

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Datasets Mentioned

BETA
KY006129
KY006156

Methods Mentioned

BETA
ELISA
genotyping

Software Mentioned

FigTree
MUSCLE
Stata
jModelTest
TreeAnnotator
BEAUti
MEGA
BEAST
SeqScape
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