Dengue type 3 virus in plasma is a population of closely related genomes: quasispecies

Journal of Virology
Wei-Kung WangShan-Chwen Chang

Abstract

Using reverse transcription-PCR and clonal sequencing of the dengue virus envelope gene derived from the plasma samples of six patients, we reported for the first time that dengue virus circulates as a population of closely related genomes. The extent of sequence diversity varied among patients, with the mean pairwise proportions of difference ranging from 0.21 to 1.67%. Genome-defective viruses were found in 5.8% of the total number of clones analyzed. Our findings on the quasispecies nature of dengue virus and the defective virus in vivo have implications with regard to the pathogenesis of dengue virus.

References

Jan 1, 1992·Current Topics in Microbiology and Immunology·J J HollandD A Steinhauer
Jun 1, 1990·Virology·K Osatomi, H Sumiyoshi
Jan 1, 1987·Annual Review of Microbiology·D A Steinhauer, J J Holland
Jan 1, 1986·Current Topics in Microbiology and Immunology·A D Barrett, N J Dimmock
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·T P Monath
Jul 1, 1997·The Journal of General Virology·D B SmithP Simmonds
Jul 17, 1998·Clinical Microbiology Reviews·D J Gubler
Dec 23, 1999·The Journal of Infectious Diseases·D W VaughnA Nisalak
Sep 2, 2000·Journal of Clinical Microbiology·W K WangC C King
Aug 27, 2004·Molecular Biology and Evolution·Yun-Huei TzengWen-Hsiung Li

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Citations

Dec 9, 2003·Trends in Microbiology·Edward C Holmes
Mar 26, 2004·Virus Research·Paola R Barrero, Alicia S Mistchenko
Sep 19, 2003·Trends in Microbiology·Christine Chevillon, Anna-Bella Failloux
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Edward C Holmes, S Susanna Twiddy
May 20, 2003·Immunology and Cell Biology·Michael S Diamond
Oct 1, 2010·Journal of Clinical Microbiology·Wei-Li HsuShih-Chieh Chang
May 1, 2012·BMC Evolutionary Biology·Alexander T CiotaLaura D Kramer
Jan 11, 2013·BMC Genomics·Kwanrutai Chin-inmanuPrapat Suriyaphol
Apr 28, 2010·BMC Microbiology·Swati Mukherjee, Kathryn A Hanley
Apr 23, 2005·Virology Journal·Catherine H ScheinWerner Braun
Feb 16, 2008·Virology Journal·Stephen J Seligman
May 23, 2008·Virology Journal·Chwan-Chuen KingJyh-Hsiung Huang
Aug 5, 2009·PLoS Neglected Tropical Diseases·Elodie DesclouxXavier De Lamballerie
May 12, 2011·PloS One·Dongsheng LiJohn Aaskov
Aug 13, 2013·PloS One·Camila Malta RomanoEsper Georges Kallas
Jun 1, 2011·PLoS Pathogens·Nicholas RenzetteTimothy F Kowalik
Apr 14, 2012·Tropical Medicine and Health·Takeshi Kurosu
Mar 22, 2014·Japanese Journal of Infectious Diseases·Takeshi KurosuSurapee Anantapreecha
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lukas HunzikerRolf M Zinkernagel
Mar 5, 2016·Genome Biology·Shuzhen Sim, Martin L Hibberd
Mar 11, 2010·Biochemical and Biophysical Research Communications·Takeshi KurosuSurapee Anantapreecha
Dec 19, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yuki KobayashiTakeo Sakai
Mar 17, 2007·Virus Research·Hiroaki Okamoto
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaofeng FanAdrian M Di Bisceglie
Aug 3, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Pakamatz KhawplodKinjiro Morimoto
Aug 13, 2013·BioMed Research International·Rosmari Rodriguez-Roche, Ernest A Gould
Jul 15, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Fernanda de Bruycker-NogueiraFlávia Barreto dos Santos
Apr 3, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Dominique Buchillet
Jul 6, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Zeng TuWei-jun Chen
Mar 7, 2003·Virology·Jerome E FosterChristine V F Carrington
Jan 9, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E DesclouxX De Lamballerie

❮ Previous
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