Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcγRIII

Thrombosis and Haemostasis
Te-Sheng LienHsin-Hou Chang

Abstract

Dengue haemorrhagic fever (DHF) typically occurs during secondary infections with dengue viruses (DENVs). Although it is generally accepted that antibody-dependent enhancement is the primary reason why patients with secondary infection are at an increased risk of developing DHF, a growing body of evidence shows that other mechanisms, such as the elicitation of antiplatelet autoantibodies by DENV nonstructural protein NS1, also play crucial roles in the pathogenesis of DHF. In this study, we developed a "two-hit" model of secondary DENV infection to examine the respective roles of DENV (first hit) and antiplatelet Igs (second hit) on the induction of haemorrhage. Mice were first exposed to DENV and then exposed to antiplatelet or anti-NS1 Igs 24 hours later. The two-hit treatment induced substantial haemorrhage, coagulopathy, and cytokine surge, and additional treatment with antagonists of TNF-α, IL-1, caspase-1, and FcγRIII ameliorated such effects. In addition, knockout mice lacking the Fcγ receptor III, Toll-like receptor 3, and inflammasome components Nlrp3 and caspase-1 exhibited considerably fewer pathological alterations than did wild type controls. These findings may provide new perspectives for developing feasible appro...Continue Reading

References

Nov 1, 1976·The American Journal of Tropical Medicine and Hygiene·R M ScottP Mansuwan
Oct 1, 1990·Seminars in Thrombosis and Hemostasis·J P Brozna
Mar 1, 1988·The American Journal of Tropical Medicine and Hygiene·S C KliksD S Burke
May 1, 1974·The American Journal of Tropical Medicine and Hygiene·W J Barnes, L Rosen
Jul 17, 1998·Clinical Microbiology Reviews·D J Gubler
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·P AndréD D Wagner
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kai-Uwe BelgeLöms Ziegler-Heitbrock
Jul 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bridget A WillsMichael Levin
Aug 26, 2003·Journal of Medical Virology·Kazunori OishiTsuyoshi Nagatake
May 1, 2004·Emerging Infectious Diseases·Day-Yu ChaoChwan-Chuen King
Aug 30, 2005·Immunology Letters·Reinhold E Schmidt, J Engelbert Gessner
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Dec 1, 2006·Journal of Leukocyte Biology·Loems Ziegler-Heitbrock
Nov 13, 2007·Lancet·Scott B Halstead
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Mar 29, 2008·Annual Review of Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Aug 6, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Chiou-Feng LinYee-Shin Lin
Jan 13, 2009·Cellular Microbiology·Yi-Ting TsaiChuan-Liang Kao
Feb 11, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Senaka Rajapakse
Oct 14, 2009·Clinical Microbiology Reviews·Byron E E MartinaAlbert D M E Osterhaus
Sep 3, 2011·Immunological Reviews·Olaf GrossJurg Tschopp
Apr 13, 2012·The New England Journal of Medicine·Cameron P SimmonsBridget Wills
Jun 8, 2012·Paediatrics and International Child Health·Scott B Halstead
Jun 27, 2013·Journal of Biomedical Science·Tsung-Ting TsaiChiou-Feng Lin

❮ Previous
Next ❯

Citations

Mar 24, 2016·Journal of Cell Science·Rahul SureshDavid M Mosser
Aug 12, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Der-Shan SunHsin-Hou Chang
Dec 12, 2018·Nature Communications·Deshni JayathilakaGathsaurie Neelika Malavige
Aug 17, 2020·International Journal of Molecular Sciences·Giulia PoliStefano Brancorsini
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Gathsaurie Neelika MalavigeGraham S Ogg
Sep 9, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Simon D LyttonLe Huu Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.