PMID: 2511337Dec 1, 1989Paper

Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes

Journal of Virology
J F BukowskiF A Ennis

Abstract

Stimulation with live dengue virus of peripheral blood mononuclear cells from a dengue virus type 4-immune donor generated virus-specific, serotype-cross-reactive, CD8+, class I-restricted cytotoxic T lymphocytes (CTL) capable of lysing dengue virus-infected cells and cells pulsed with dengue virus antigens of all four serotypes. These CTL lysed autologous fibroblasts infected with vaccinia virus-dengue virus recombinant viruses containing the E gene or several nonstructural dengue virus type 4 genes. These results demonstrate that both dengue virus structural and nonstructural proteins are targets for the cytotoxic T-cell-mediated immune response to dengue virus and suggest that serotype-cross-reactive CD8+ CTL may be important mediators of viral clearance and of virus-induced immunopathology during secondary dengue virus infections.

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Citations

Jul 23, 2002·Journal of Virology·Christine A KingJean S Marshall
Mar 24, 2006·Viral Immunology·Joseph E BlaneyStephen S Whitehead
Apr 14, 2012·Tropical Medicine and Health·Ichiro KuraneFrancis A Ennis
Feb 19, 2010·Journal of Medical Virology·Jinsheng WenLifang Jiang
Jun 15, 2007·Nature Reviews. Microbiology·Stephen S WhiteheadBrian R Murphy
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iva ZivnaAlan L Rothman
Mar 4, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chen-Yu TsaiSoon Boon Justin Wong
Feb 11, 2015·Human Vaccines & Immunotherapeutics·Joseph D ComberRamila Philip
Oct 10, 1998·Journal of Virology·J JamesonF A Ennis
Apr 20, 1999·Virology·A L Rothman, F A Ennis
May 1, 1993·Molecular Immunology·C LeclercV Deubel
Apr 1, 1996·Journal of Virology·W E DemkowiczF A Ennis
Oct 1, 1990·Clinical Microbiology Reviews·E A Henchal, J R Putnak

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