Denitrosation of N-nitrosomorpholine by liver microsomes; possible role of cytochrome P-450

Cancer Letters
K E AppelW Kunz

Abstract

Liver microsomes from male mice and rats were incubated with N-nitrosomorpholine (MoNA) and an NADPH-regenerating system. The formation of nitrite was measured after induction or inhibition of the microsomal monooxygenase system. Pretreatment of the animals with phenobarbital (PB) enhanced nitrite formation by about 200%, while 3-methylcholanthrene (3-MC)-induction showed no exceptional effects. Various specific inhibitors of the monooxygenase function including carbon monoxide decreased nitrite formation. In conjunction with results obtained by spectra studies it is suggested that N-nitrosomorpholine is denitrosated by a reduction process in which cytochrome (cyt.) P-450 seems to be involved. Nitricoxide formed is partly converted to nitrite under these conditions.

References

Jun 27, 1977·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·J C ArcosM F Argus
Jul 25, 1977·Biochemical and Biophysical Research Communications·A N SaprinL H Piette
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Jan 23, 1974·Biochemical and Biophysical Research Communications·C Lind, L Ernster
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Aug 1, 1971·Archives of Biochemistry and Biophysics·J A PetersonA G Hildebrandt

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Citations

Jan 1, 1987·Archives of Toxicology·K E AppelA G Hildebrandt
Jan 1, 1984·Die Naturwissenschaften·R Preussmann
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·J ChenJ H Weisburger
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·K E AppelA G Hildebrandt
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·M SchwarzW Kunz
Jan 1, 1991·Chemico-biological Interactions·T ScheperA G Hildebrandt
Jan 1, 1986·The International Journal of Biochemistry·E K Marker, A P Kulkarni
Sep 1, 1987·Mutation Research·J B Guttenplan
Dec 1, 1984·Toxicology Letters·K E AppelA G Hildebrandt
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M B Kroeger-KoepkeC J Michejda
Feb 1, 1985·Chemico-biological Interactions·K E AppelA G Hildebrandt
Mar 1, 1981·Chemico-biological Interactions·E B BritteboH Tjälve
Sep 1, 1986·Journal of Biochemical Toxicology·E K Marker, A P Kulkarni
Oct 1, 1981·Biochemical Pharmacology·K E AppelM Wiessler

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