Denosumab for Elderly Men with Osteoporosis: A Cost-Effectiveness Analysis from the US Payer Perspective

Journal of Osteoporosis
S SilvermanE Orwoll

Abstract

Purpose. To evaluate the cost-effectiveness of denosumab versus other osteoporotic treatments in older men with osteoporosis from a US payer perspective. Methods. A lifetime cohort Markov model previously developed for postmenopausal osteoporosis (PMO) was used. Men in the model were 78 years old, with a BMD T-score of -2.12 and a vertebral fracture prevalence of 23%. During each 6-month Markov cycle, patients could have experienced a hip, vertebral or nonhip, nonvertebral (NHNV) osteoporotic fracture, remained in a nonfracture state, remained in a postfracture state, or died. Background fracture risks, mortality rates, persistence rates, health utilities, and medical and drug costs were derived from published sources. Previous PMO studies were used for drug efficacy in reducing fracture risk. Lifetime expected costs and quality-adjusted life-years (QALYs) were estimated for denosumab, generic alendronate, risedronate, ibandronate, teriparatide, and zoledronate. Results. Denosumab had an incremental cost-effectiveness ratio (ICER) of $16,888 compared to generic alendronate and dominated all other treatments. Results were most sensitive to changes in costs of denosumab and the relative risk of hip fracture. Conclusion. Despite a...Continue Reading

References

Jun 15, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L J MeltonW M O'Fallon
Sep 9, 2000·The New England Journal of Medicine·E OrwollA Lombardi
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Feb 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisB Jonsson
Feb 11, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R HasseriusUNKNOWN European Vertebral Osteoporosis Study
Nov 1, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisB Jonsson
Nov 1, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O JohnellB Jönsson
Nov 17, 2005·Archives of Internal Medicine·Daniel H SolomonM Alan Brookhart
Jul 21, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Janel HanmerDennis G Fryback
Jul 25, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D WeyckerG Oster
Sep 30, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F BorgströmJ A Kanis
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Dennis M BlackUNKNOWN FLEX Research Group
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A N A TostesonUNKNOWN National Osteoporosis Foundation Guide Committee
Apr 19, 2008·Internal Medicine·Takafumi MajimaKazuwa Nakao
Mar 10, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T PeasgoodJ E Brazier
Aug 13, 2009·The New England Journal of Medicine·Steven R CummingsUNKNOWN FREEDOM Trial
Oct 12, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B JönssonJ A Kanis
Feb 3, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E LandfeldtF Borgström
Mar 18, 2011·The Journal of Clinical Endocrinology and Metabolism·S BoonenM McClung
Sep 20, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N FreemantleUNKNOWN DAPS Investigators
Sep 29, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisC Cooper
Oct 7, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael R McClungSteven R Cummings
Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Eric OrwollSteven Boonen
Jul 11, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S K BrennemanY Fan
Nov 2, 2012·The New England Journal of Medicine·Steven BoonenEric Orwoll

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Citations

Nov 2, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M HiligsmannS Silverman
Mar 9, 2020·Archives of Osteoporosis·Julie MartinAnne-Marie Schott
Mar 8, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T ImaiUNKNOWN A-TOP (Adequate Treatment of Osteoporosis) Research Group
Jun 24, 2020·Journal of Bone Metabolism·Chaiho Jeong, Jeonghoon Ha
Oct 13, 2021·Archives of Osteoporosis·Ben JohnsonBjörn Stollenwerk

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