Denosumab for treatment of immobilization-related hypercalcemia in a patient with end-stage renal disease

CEN Case Reports
Atsuko UeharaYugo Shibagaki

Abstract

The efficacy and safety of denosumab for the treatment of immobilization-related hypercalcemia in end-stage renal disease remain uncertain. We describe the case of a hemodialysis patient with immobilization-related hypercalcemia who was successfully treated with denosumab. A 79-year-old man admitted for hemodialysis after sustaining an acute kidney injury developed immobilization-related hypercalcemia due to the impairment resulting from an acute myocardial infarction, acute heart failure, and catheter-related bloodstream infection. After admission, the patient's corrected serum calcium rose to 12.9 from 8.8 mg/dL. A bisphosphonate (alendronate) was administered, but it was ineffective. Subsequently, treatment with denosumab proved to be effective and his corrected serum calcium level declined to 9.3 mg/dL within 1 week. Hypocalcemia, which is an adverse effect of denosumab, was prevented using active vitamin D and calcium supplementation, and his calcium level stabilized. Thus, our case demonstrates that denosumab is a viable therapeutic option for dialysis patients experiencing immobilization-related hypercalcemia.

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Dec 6, 2018·Clinical Nuclear Medicine·François SommeCéline Heimburger
Feb 18, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Ryan M PrattKarthik K Tennankore
May 2, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C ThongprayoonW Cheungpasitporn
Jun 5, 2021·BMJ Case Reports·Jesse Marc TetteroAlbertus Jozef Kooter
May 22, 2021·Annals of Pediatric Endocrinology & Metabolism·Emrah GünAhmet Rüçhan Akar
Oct 18, 2021·American Journal of Physical Medicine & Rehabilitation·Jean-Baptiste MeslandPhilippe Hantson

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