Denosumab-related osteonecrosis of the jaw following non-surgical periodontal therapy: A case report

Journal of Clinical Periodontology
Márcio Diniz-FreitasJacobo Limeres

Abstract

Osteonecrosis of the jaw associated with bisphosphonates is currently called medication-related osteonecrosis of the jaw (MRONJ), given that in addition to bisphosphonates, jaw osteonecrosis has been related to the administration of other antiresorptive and antiangiogenic drugs, such as denosumab, sunitinib, bevacizumab and ipilimumab. A 77-year-old patient with osteoporosis treated with subcutaneous injections of denosumab at an interval of 6 months is presented. The patient developed MRONJ after receiving a non-surgical periodontal therapy. Although the MRONJ was initially classified as a stage I lesion in this patient, cone beam computed tomography images confirmed the presence of a significant osteolytic lesion. Treatment consisted of the administration of chlorhexidine mouthwash and systemic doxycycline, exodontia of the involved teeth, sequestrectomy and complete surgical debridement of the necrotic bone. To our knowledge, this is the first case reported in the literature of MRONJ following non-surgical periodontal therapy in a patient with osteoporosis treated with denosumab. The risk of MRONJ development after a periodontal procedure and how to prevent this complication are still unknown.

References

Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
Jan 25, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R G G RussellM J Rogers
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Eric R Carlson, John D Basile
Nov 10, 2009·The Oncologist·Pinelopi Kleio PalaskaAthanasios I Zavras
Jan 5, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Tim Van den WyngaertJan B Vermorken
Jan 7, 2011·Expert Opinion on Drug Safety·Ioannis CharopoulosPeter V Giannoudis
Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H HenryHoward Yeh
Nov 25, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Socrates PapapoulosHenry G Bone
Jul 31, 2012·International Journal of Oral and Maxillofacial Surgery·T YamazakiK Bessho
Aug 21, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Matthew S EpsteinJoel B Epstein
Sep 6, 2012·Reumatología clinica·Lucía Silva-FernándezEstibaliz Loza
Dec 26, 2012·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Sarina E C PichardoJ P Richard van Merkesteyn
Feb 1, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Eric R Carlson
May 27, 2014·The British Journal of Oral & Maxillofacial Surgery·Alberto BedogniGiuseppina Campisi
Sep 23, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroFelice O'Ryan
Sep 27, 2014·British Dental Journal·A Robinson, C Scully
Nov 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aliya A KhanUNKNOWN International Task Force on Osteonecrosis of the Jaw
Dec 30, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Oliver RistowChristoph Pautke
Sep 26, 2015·Future Oncology·Sonali Thosani, Mimi I Hu
Dec 24, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A LiptonA Braun
Feb 2, 2016·Medicina oral, patología oral y cirugía bucal·Márcio Diniz-Freitas, Jacobo Limeres
May 29, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Sarina E C Pichardo, J P Richard van Merkesteyn
Feb 6, 2017·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Fredrik HallmerMorten Enersen
Apr 30, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T HasegawaUNKNOWN Japanese Study Group of Cooperative Dentistry with Medicine (JCDM)
May 22, 2017·The Journal of the American Dental Association·Mohamed El-RabbanyAmir Azarpazhooh
May 23, 2017·F1000Research·Seiji Fukumoto, Toshio Matsumoto
Jun 7, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Saki HayashidaMasahiro Umeda
Jul 9, 2017·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Suad AljohaniSven Otto
Nov 6, 2017·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Noam YaromRan Yahalom

❮ Previous
Next ❯

Citations

Dec 29, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Benjamin PallaEric R Carlson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.