Dense and overlapping innervation of pyramidal neurons by chandelier cells

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Melis InanRafael Yuste

Abstract

Chandelier (or axo-axonic) cells are a distinct group of GABAergic interneurons that innervate the axon initial segments of pyramidal cells and thus could have an important role controlling the activity of cortical circuits. To understand their connectivity, we labeled upper layers chandelier cells (ChCs) from mouse neocortex with a genetic strategy and studied how their axons contact local populations of pyramidal neurons, using immunohistochemical detection of axon initial segments. We studied ChCs located in the border of layers 1 and 2 from primary somatosensory cortex and found that practically all ChC axon terminals contact axon initial segments, with an average of three to five boutons per cartridge. By measuring the number of putative GABAergic synapses in initial segments, we estimate that each pyramidal neuron is innervated, on average, by four ChCs. Additionally, each individual ChC contacts 35-50% of pyramidal neurons within the areas traversed by its axonal arbor, with pockets of very high innervation density. Finally, ChCs have similar innervation patterns at different postnatal ages (P18-P90), with only relatively small lateral expansions of their arbor and increases in the total number of their cartridges during...Continue Reading

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Citations

Jun 1, 2013·Science·Stewart Anderson, Douglas Coulter
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Winnie WefelmeyerJuan Burrone
Sep 1, 2015·Trends in Neurosciences·Camille AlleneAlberto Bacci
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Jan 21, 2014·Current Opinion in Neurobiology·Mahesh M KarnaniRafael Yuste
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May 21, 2016·Frontiers in Neural Circuits·Yiqing WangDaniel R Wyskiel
Jul 6, 2016·Trends in Neurosciences·Andrew J Trevelyan
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Feb 20, 2015·The Journal of Experimental Biology·Melissa M Rolls, Timothy J Jegla

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