Dense deposit disease in association with monoclonal gammopathy of unknown significance

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
F Sepandj, A Trillo

Abstract

Several renal pathologic entities have been reported in patients with lymphoplasmacytic disorders with their typical excess immunoglobulin production. We report dense deposit disease in a patient who was discovered to have an IgG kappa monoclonal protein without clinical evidence of underlying lymphoplasmacytic malignancy during investigation for chronic renal failure with associated nephrotic range proteinuria. This case is unusual since dense deposit disease occurs only rarely in older patients and has not been reported in association with monoclonal gammopathy of unknown significance. Because of the diversity of renal lesions associated with lymphoplasmacytic disorders, renal biopsy is necessary to assess the type of renal lesion in this patient population.

Citations

Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Prue A HillDavid G Goodman
Mar 13, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas D BarbourH Terence Cook
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Frank BridouxGuy Touchard
Dec 9, 2014·Indian Journal of Nephrology·S ThomasG T John
Oct 29, 2013·Seminars in Nephrology·Thomas D BarbourH Terence Cook
Apr 30, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ladan ZandSanjeev Sethi
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Feb 11, 2015·Advances in Anatomic Pathology·Turki Al-HussainMohammed Akhtar
Apr 21, 2017·International Urology and Nephrology·Mariana CiocchiniCarlos G Musso

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