Dense neuron clustering explains connectivity statistics in cortical microcircuits

PloS One
V V KlinshovTomoki Fukai

Abstract

Local cortical circuits appear highly non-random, but the underlying connectivity rule remains elusive. Here, we analyze experimental data observed in layer 5 of rat neocortex and suggest a model for connectivity from which emerge essential observed non-random features of both wiring and weighting. These features include lognormal distributions of synaptic connection strength, anatomical clustering, and strong correlations between clustering and connection strength. Our model predicts that cortical microcircuits contain large groups of densely connected neurons which we call clusters. We show that such a cluster contains about one fifth of all excitatory neurons of a circuit which are very densely connected with stronger than average synapses. We demonstrate that such clustering plays an important role in the network dynamics, namely, it creates bistable neural spiking in small cortical circuits. Furthermore, introducing local clustering in large-scale networks leads to the emergence of various patterns of persistent local activity in an ongoing network activity. Thus, our results may bridge a gap between anatomical structure and persistent activity observed during working memory and other cognitive processes.

References

Oct 18, 2016·Nature Neuroscience·Anthony Holtmaat, Pico Caroni
Jan 15, 2016·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·V V Klinshov, Igor Franović
Jul 11, 2017·Frontiers in Computational Neuroscience·Hesam SetarehWulfram Gerstner
Mar 25, 2019·F1000Research·Gabriele Scheler
Jul 28, 2017·Journal of Computational Neuroscience·Áine ByrneStephen Coombes
Jun 5, 2017·Scientific Reports·Amir GoldentalIdo Kanter
May 16, 2019·Network Neuroscience·Nathaniel RodriguezYong-Yeol Ahn
May 29, 2018·ELife·Azadeh Yazdan-ShahmoradPhilip N Sabes

Citations

Jun 22, 1987·The Journal of Comparative Neurology·A Peters, D A Kara
Aug 15, 1985·The Journal of Comparative Neurology·A PetersK M Harriman
Jan 1, 1972·Biophysical Journal·H R Wilson, J D Cowan
Apr 1, 1997·Brain : a Journal of Neurology·V B MOUNTCASTLE
Sep 1, 1997·Cerebral Cortex·Henry Markram
Oct 15, 1990·Physical Review. a·C K PengH E Stanley
Jan 5, 2002·Neuron·Per Jesper SjöströmSacha Nelson
Jul 23, 2002·Nature Neuroscience·Alexei A KoulakovJohn E Lisman
Dec 6, 2002·Cerebral Cortex·Alex M Thomson, A Peter Bannister
Dec 6, 2002·Cerebral Cortex·Ralph D Freeman
Jan 22, 2003·Nature Neuroscience·Daniel L Adams, Jonathan C Horton
Jun 19, 2003·The Journal of Physiology·Carl HolmgrenYuri Zilberter
Jun 20, 2003·Journal of Neurocytology·Javier DeFelipeJon I Arellano
Sep 15, 2004·Experimental Brain Research·Kathleen S Rockland, Noritaka Ichinohe
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tom BinzeggerKevan A C Martin
Jan 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nir KalismanHenry Markram
Jan 18, 2005·Nature Reviews. Neuroscience·Tatiana Pasternak, Mark W Greenlee
Feb 25, 2005·Nature·Yumiko YoshimuraEdward M Callaway
Mar 2, 2005·PLoS Biology·Sen SongDmitri B Chklovskii
May 20, 2005·Nature·Xiaoqin WangLi Liang
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Pak-Ming Lau, Guo-Qiang Bi
Sep 29, 2005·PLoS Biology·Robert J PrillAndre Levchenko
Feb 6, 2007·Trends in Neurosciences·Dietmar Plenz, Tara C Thiagarajan
Apr 7, 2007·Journal of Computational Neuroscience·Katsunori Kitano, Tomoki Fukai
Jun 8, 2007·The European Journal of Neuroscience·Yasuhiro TsuboTomoki Fukai
Mar 15, 2008·Science·Gianluigi MongilloMisha Tsodyks
Apr 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert J Morgan, Ivan Soltesz
Jun 24, 2008·Network : Computation in Neural Systems·V V Klinshov, V I Nekorkin
Mar 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexei A KoulakovAnthony M Zador
Jun 9, 2009·PLoS Computational Biology·Hiroshi Okamoto, Tomoki Fukai
Jul 6, 2010·Nature·Ifije E OhiorhenuanJonathan D Victor
Sep 14, 2010·Current Opinion in Neurobiology·Dmitri B ChklovskiiLouis K Scheffer
Dec 22, 2010·Neuron·Lina YassinAlison L Barth
Mar 4, 2011·Frontiers in Computational Neuroscience·Olaf Sporns
Mar 5, 2011·Frontiers in Computational Neuroscience·Chris Gaiteri, Jonathan E Rubin

Related Concepts

C3 gene
Cortex Bone Disorders
Adrenal Cortex Diseases
Calcium
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Neurons
Weighing Patient
N-Methylaspartate
Complement 3
Synaptic Connectivity

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.