Densities of rectal peptide YY and somatostatin cells as biomarkers for the diagnosis of irritable bowel syndrome

Peptides
M El-SalhyT Hausken

Abstract

Irritable bowel syndrome (IBS) is a common chronic disorder. IBS diagnosis is a diagnosis of exclusion since there are no blood tests, radiological or endoscopic examinations for this disorder. Although several attempts have been made to develop a symptoms-based diagnosis, such systems are not widely used in clinics. Several tests and examinations measuring pathological findings in IBS have been considered for the diagnosis of IBS, but none of them has proved useful as a biomarker. Abnormalities in the cell densities of rectal peptide YY (PYY) and somatostatin cells have been reported in IBS patients. The aim of the present study was to determine the utility of these abnormalities as biomarkers for the diagnosis of IBS. Patients with IBS established according to Rome III criteria (n = 101) were included in this study (71 females and 30 males with a mean age of 35 years; range 18-61 years), and 62 healthy subjects (38 females and 24 males with a mean age of 41 years; range 18-65 years) were recruited as controls. Both the patients and controls underwent colonoscopy during which rectal biopsy samples were taken. The tissue samples were immunostained for PYY and somatostatin, and the number of stained cells was quantified relative...Continue Reading

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Citations

Apr 17, 2015·Nutrition Journal·Magdy El-Salhy, Doris Gundersen
Jan 21, 2017·Scientific Reports·Ahmed M HassanPeter Holzer
Jul 15, 2015·World Journal of Gastroenterology : WJG·Magdy El-Salhy
Oct 16, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dervla O'Malley
Jul 15, 2015·Expert Review of Gastroenterology & Hepatology·Magdy El-Salhy
Apr 12, 2017·Expert Review of Proteomics·Athanasios TsigaridasMaria Gazouli
Sep 4, 2015·World Journal of Gastroenterology : WJG·Magdy El-SalhyTrygve Hausken
Nov 3, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriHoussam Halawi

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