Density histogram analysis of unenhanced hepatic computed tomography in patients with diffuse liver diseases

Journal of Computer Assisted Tomography
Gerald A FritzReinhard Groell

Abstract

The aim of the study was to assess the potential of density histogram analysis of unenhanced hepatic computed tomography (CT) in the diagnosis and differentiation of diffuse liver diseases. Twenty-six patients with normal liver parenchyma, 35 patients with diffuse steatosis, 14 patients with acute steatohepatitis, 15 patients with active alcoholic cirrhosis, 23 patients with inactive alcoholic cirrhosis, 15 patients with virus-induced cirrhosis, and 8 patients with hemochromatosis underwent unenhanced hepatic CT. All diffuse liver diseases and the absence of diffuse liver disease were histologically proven. Quantitative analysis of unenhanced liver parenchyma was performed in each patient. The hepatic density histogram showed no significant differences in kurtosis and skewness between the groups (P > 0.05). Except for steatosis, active alcoholic cirrhosis, and hemochromatosis, diffuse liver diseases led to similar densities of liver parenchyma in unenhanced hepatic CT. A reliable diagnosis and differentiation of diffuse liver diseases on the basis of density histogram analysis is not possible.

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Citations

Feb 6, 2016·Digestive Diseases and Sciences·Sonja KinnerTakeshi Yokoo
Nov 23, 2006·European Journal of Radiology·Musturay Karcaaltincaba, Okan Akhan
Nov 22, 2008·Journal of Hepatology·Susanne BonekampJeanne Clark
Jun 12, 2012·International Journal of Radiation Oncology, Biology, Physics·Christopher C HowellsMoyed Miften
Mar 13, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Se Jin NamJin Young Kwak
Sep 8, 2018·World Journal of Hepatology·Qian LiAnthony E Samir
Sep 15, 2020·Clinical Liver Disease·Amreen M DinaniPonni Perumalswami
Jun 23, 2021·Clinical and Molecular Hepatology·Seong Hee KangUNKNOWN Korean Association for the Study of the Liver (KASL)

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