Density of bone metastatic lesions increases after radiotherapy in patients with breast cancer

Journal of Radiation Research
Qian WangShikai Wu

Abstract

The aim of this study was to assess local response to radiotherapy (RT) in a quantitative manner by evaluating the bone density of metastases. Spinal and pelvic bone metastases in 44 patients with breast cancer who were treated between May 2010 and December 2016 were retrospectively assessed. Bone density values of irradiated and unirradiated bone metastases before, 1-3 months after, 4-6 months after, and 7-9 months after RT were compared. At each time point, mean bone density ± standard deviation values were measured in Hounsfield units (HU) from computed tomography (CT) scans. Student's t-test was used for statistical analyses of the differences in bone density and for univariate analysis of the prognostic factors for differences in bone density at various time points after RT. Mean bone densities in irradiated and unirradiated bone metastases before RT were 297.31 ± 211.93 HU and 326.29 ± 228.61 HU, respectively. At the subsequent three time points examined, the mean bone density values in the irradiated and unirradiated bone metastases were: 61.97 ± 78.58 HU (P = 0.000) and 36.93 ± 52.49 HU (P = 0.001); 149.07 ± 133.27 HU (P = 0.000) and 68.40 ± 101.10 HU (P = 0.000); and 183.94 ± 168.30 HU (P = 0.000) and 88.21 ± 159.49 HU...Continue Reading

References

Feb 1, 1990·British Journal of Cancer·P F BruningA van Enk
Nov 1, 1996·The British Journal of Dermatology·S W KooS K Hann
Nov 11, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S Koswig, V Budach
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L ShapiroM Leboff
Feb 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Jackson Sai-Yiu WuUNKNOWN Cancer Care Ontario Practice Guidelines Initiative Supportive Care Group
Apr 6, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Edward ChowCyril Danjoux
Aug 24, 2006·Breast Cancer Research : BCR·A Ugur UralM Ali Ozcan
Apr 9, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Luis CostaAndrew Wardley
Mar 18, 2010·Nature Reviews. Clinical Oncology·Dirk RadesJanet L Abrahm
Dec 2, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·E ChowS Lutz
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam B LustbergCharles L Shapiro
Apr 3, 2013·European Journal of Pharmacology·Jan C DroogerAgnes Jager
Apr 2, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ingmar SchlamppHarald Rief
Jul 12, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Harald RiefUNKNOWN German Bone Research Group
Jul 15, 2015·Clinical Epigenetics·Christian BuschSascha Venturelli
Sep 10, 2015·Technology in Cancer Research & Treatment·Rachel McDonaldArjun Sahgal
Aug 5, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shunsuke TsuzukiYusuke Shiozawa
Aug 27, 2016·International Journal of Molecular Sciences·Vassilis KoulouliasJohn R Kouvaris
Jul 11, 2018·Prostate Cancer and Prostatic Diseases·Kurt MillerDiana Lüftner

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