Density of neoplastic lymphoid infiltrate, CD8+ T cells, and CD1a+ dendritic cells in mycosis fungoides

Journal of Clinical Pathology
G GoteriG Fabris

Abstract

CD8+ T cells and epidermal/dermal dendritic cells expressing CD1a are found among neoplastic CD4+ T cells in mycosis fungoides (MF) lesions. This study analysed the relation of CD8+ tumour infiltrating lymphocytes (TILs), CD1a+ epidermal Langerhan's cells (LCs), and dermal dendritic cells (DDCs) to clinicopathological parameters in 46 MF cases. Pretreatment diagnostic biopsy specimens of 46 MF cases were submitted to histological analysis and immunohistochemistry. Four histological grades were defined based on the density of the neoplastic infiltrate: grade 1 (mild superficial perivascular infiltrate), grade 2 (moderate superficial perivascular infiltrate with some tendency to confluence), grade 3 (pronounced superficial band-like infiltrate), and grade 4 (deep nodular infiltrate). Epidermotropism was scored as low, moderate, or high. Numbers of CD8+ T cells and of dermal and epidermal CD1a+ cells were scored as 1 (low), 2 (moderate), and 3 (high). Correlations between these parameters and clinical data (age, sex, clinical type of lesions, stage, response to treatment, and recurrence) were analysed by the chi(2) test. Numbers of TILs and DDCs were associated with subepidermal infiltrates, being lower in less dense infiltrates, ...Continue Reading

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Citations

Jun 9, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Madoka SatoSoji Yamazaki
Dec 19, 2012·Indian Journal of Dermatology·Rajalakshmi Tirumalae, Poonam K Panjwani
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Jun 14, 2016·BioMed Research International·Ieva SauliteUlrike Wehkamp
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adriana Garcia-HerreraElias Campo

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