Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Brandon C McKinneyRobert A Sweet

Abstract

Previously, we demonstrated that dendritic spine density (DSD) in deep layer 3 of the primary auditory cortex (A1) is lower, due to having fewer small spines, in subjects with schizophrenia (SZ) than non-psychiatric control (NPC) subjects. We also previously demonstrated that microtubule-associated-protein-2 immunoreactivity (MAP2-IR) in A1 deep layer 3 is lower, and positively correlated with DSD, in SZ subjects. Here, we first sought to confirm these findings in an independent cohort of 25 SZ-NPC subject pairs (cohort 1). We used immunohistochemistry and confocal microscopy to measure DSD and MAP2-IR in A1 deep layer 3. Consistent with previous studies, both DSD and MAP2-IR were lower in SZ subjects. We then tested the hypothesis that MAP2-IR mediates the effect of SZ on DSD in a cohort of 45 SZ-NPC subject pairs (combined cohort) that included all subjects from cohort 1 and two previously studied cohorts. Based on the distribution of MAP2-IR values in NPC subjects, we categorized each SZ subject as having either low MAP2-IR (SZ MAP2-IR(low)) or normal MAP2-IR (SZ MAP2-IR(normal)). Among SZ MAP-IR(low) subjects, mean DSD was significantly lower than in NPC subjects. However, mean DSD did not differ between SZ MAP2-IR(normal) ...Continue Reading

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Citations

Jan 1, 2021·Developmental Neurobiology·Martyna PekalaKatarzyna Kalita
Feb 3, 2021·Molecular Psychiatry·M J GrubishaR A Sweet
May 10, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Arash NazeriAristotle N Voineskos
May 30, 2021·Nature Reviews. Neuroscience·Haruo KasaiTaro Toyoizumi
Aug 3, 2021·Frontiers in Molecular Neuroscience·Melanie J GrubishaMatthew L MacDonald
Dec 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Melanie J GrubishaRobert A Sweet

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