Density-property relationships in mineralized collagen-glycosaminoglycan scaffolds

Acta Biomaterialia
Biraja P Kanungo, L J Gibson

Abstract

Mineralized collagen-glycosminoglycan scaffolds have previously been fabricated by freeze-drying a slurry containing a co-precipitate of calcium phosphate, collagen and glycosaminoglycan. The mechanical properties of the scaffold are low (e.g. the dry Young's modulus for a 50 wt.% mineralized scaffold is roughly 780 kPa). Our previous attempt to increase the mechanical properties of the scaffold by increasing the mineralization (from 50 to 75 wt.%) was unsuccessful due to defects in the more mineralized scaffold. In this paper, we describe a new technique to improve the mechanical properties by increasing the relative density of the scaffolds. The volume fraction of solids in the slurry was increased by vacuum-filtration. The slurry was then freeze-dried in the conventional manner to produce scaffolds with relative densities between 0.045 and 0.187 and pore sizes of about 100-350 microm, values appropriate for bone growth. The uniaxial compressive stress-strain curves of the scaffolds indicated that the Young's modulus in the dry state increased from 780 to 6500 kPa and that the crushing strength increased from 39 to 275 kPa with increasing relative density. In the hydrated state, the Young's modulus increased from 6.44 to 34.8...Continue Reading

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Citations

Oct 15, 2013·Journal of Pharmaceutical Sciences·Sharmila Devi, Daryl Williams
Jun 5, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Steven R CaliariBrendan A C Harley
Aug 27, 2013·Journal of the Mechanical Behavior of Biomedical Materials·D W WeisgerberB A C Harley
Jul 16, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sharmila Devi, Daryl R Williams
Apr 7, 2010·Biomaterials·Karolina A Corin, Lorna J Gibson
Feb 27, 2014·Tissue Engineering. Part a·Steven R Caliari, Brendan A C Harley
May 3, 2018·Journal of Biomaterials Science. Polymer Edition·Xiaodong XuDongfang Liu
May 6, 2015·Biomaterials Science·Daniel W WeisgerberBrendan A C Harley
Jun 6, 2019·Journal of Biomaterials Science. Polymer Edition·Xiaodong XuHongcan Shi
Apr 7, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Marley J DeweyBrendan A C Harley
May 24, 2019·Acta Biomaterialia·Aleczandria S TiffanyBrendan A C Harley

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