Dental alveolar bone defects related to Vitamin D and calcium status

The Journal of Steroid Biochemistry and Molecular Biology
J L DavideauAriane Berdal

Abstract

Vitamin D is important for skeletal development, growth, and homeostasis but has been sparsely studied in the oro-facial bone. Dental alveolar bone anchors teeth to mandible and maxilla bones via a periodontal ligament. Its formation and maintenance are strictly dependent on the presence of tooth organs and it is characterized by a high turnover rate. In order to study the role of Vitamin D and the calcium status on dental alveolar bone formation, microradiographic and histologic comparison of wild-type, Vitamin D receptor null mutant (VDR (-/-) hypo- and normo-calcemic mice and tissues were performed at 2 months. In hypo-calcemic VDR (-/-) mice, alveolar bone was hypomineralized and demonstrated a cellular and matrix organization, similar to the immature woven bone. In normo-calcemic VDR (-/-) mice, mineralization of dental alveolar bone appeared normal, but bone was morphologically abnormal in some specific anatomical locations. These data show that Vitamin D and calcium status may control the formation of dental alveolar bone. The differences of phenotype between hypo- and normo-calcemic VDR null mutant mice suggested a specific Vitamin D control of alveolar bone formation by the Vitamin D nuclear receptor pathway.

Citations

Aug 28, 2012·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Maria Luiza S Simas Netta FontanaPaula Cristina Trevilatto
Dec 4, 2014·Journal of Clinical Periodontology·Alexander FüglGabriella Dvorak
Dec 28, 2010·Archives of Oral Biology·Xueming ZhangHuw F Thomas
Oct 12, 2010·Journal of Dental Research·V DescroixA Berdal
Jan 18, 2018·Nutrition Journal·Johanna GyllPernilla Lif Holgerson
Nov 21, 2013·International Journal of Cancer. Journal International Du Cancer·Nicolás García-ArenzanaMarina Pollán
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Mar 17, 2020·Journal of the Indian Society of Pedodontics and Preventive Dentistry·Victoria Guru AribamArvind Ramanathan
Oct 29, 2020·Journal of Family Medicine and Primary Care·Shilpa KalraPriyank Rai
Sep 1, 2021·Clinical Oral Investigations·Erika Calvano KüchlerChristian Kirschneck

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