Dental Apical Papilla as Therapy for Spinal Cord Injury

Journal of Dental Research
P De BerdtA des Rieux

Abstract

Stem cells of the apical papilla (SCAP) represent great promise regarding treatment of neural tissue damage, such as spinal cord injury (SCI). They derive from the neural crest, express numerous neurogenic markers, and mediate neurite outgrowth and axonal targeting. The goal of the present work was to investigate for the first time their potential to promote motor recovery after SCI in a rat hemisection model when delivered in their original stem cell niche-that is, by transplantation of the human apical papilla tissue itself into the lesion. Control groups consisted of animals subjected to laminectomy only (shams) and to lesion either untreated or injected with a fibrin hydrogel with or without human SCAP. Basso-Beattie-Bresnahan locomotor scores at 1 and 3 d postsurgery confirmed early functional decline in all SCI groups. This significant impairment was reversed, as seen in CatWalk analyses, after transplantation of apical papilla into the injured spinal cord wound, whereas the other groups demonstrated persistent functional impairment. Moreover, tactile allodynia did not develop as an unwanted side effect in any of the groups, even though the SCAP hydrogel group showed higher expression of the microglial marker Iba-1, which...Continue Reading

References

Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Apr 30, 1996·Brain Research. Developmental Brain Research·H L ChengE L Feldman
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Fengfu LiMay Griffith
Feb 6, 2004·Journal of Neurochemistry·Keiko OhsawaShinichi Kohsaka
Jun 23, 2009·Stem Cells·Agnieszka ArthurSimon A Koblar
Feb 14, 2013·Journal of Endodontics·Nikita B RuparelAnibal Diogenes
Jul 13, 2013·Clinical Oral Investigations·W MartensI Lambrichts
Aug 7, 2013·International Journal of Pharmaceutics·Eduardo AnsorenaAnne des Rieux
Aug 16, 2013·Journal of Biomedical Materials Research. Part a·Anne des RieuxVéronique Préat
May 20, 2014·Tissue Engineering. Part a·Jose Flavio A de AlmeidaAnibal Diogenes
Jun 27, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elisa R ZanierMaria-Grazia De Simoni
Aug 26, 2014·Journal of Endodontics·Julie VanackerAnne des Rieux
Feb 13, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kohki MatsubaraAkihito Yamamoto
Apr 4, 2015·Regenerative Medicine·Loïc GermainAnne des Rieux

❮ Previous
Next ❯

Citations

Dec 24, 2015·Frontiers in Physiology·Min Oh, Jacques E Nör
Apr 6, 2016·Archives of Oral Biology·Stefanie Bressan WerleLuciano Casagrande
Mar 24, 2016·Stem Cells International·Satoru MorikawaTaneaki Nakagawa
Oct 1, 2016·Stem Cells International·Jessica RatajczakPetra Hilkens
Nov 8, 2016·Stem Cells International·Athina Bakopoulou, Imad About
Sep 17, 2016·Journal of Biomedical Materials Research. Part a·Aiswarya ViswanathAnne des Rieux
Oct 24, 2015·Journal of Dental Research·O D Klein, J E Nör
Jan 16, 2016·Cellular and Molecular Life Sciences : CMLS·John BiancoAnne des Rieux
Aug 9, 2018·Frontiers in Bioengineering and Biotechnology·Ola A Nada, Rania M El Backly
Mar 6, 2019·BioMed Research International·Jun KangFang Huang
Jun 25, 2020·International Journal of Molecular Sciences·Ji Won YangHyung-Sik Kim
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Dixin CuiMian Wan
Apr 8, 2019·Archives of Oral Biology·Boon Chin HengChengfei Zhang

❮ Previous
Next ❯

Software Mentioned

GraphPad
CatWalk
ImageJ
GraphPad PRISM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.