PMID: 2098708Dec 1, 1990Paper

Dental caries in congenitally athymic rats

Oral Microbiology and Immunology
W E StackR Kent

Abstract

The importance of the immune response in dental infection was evaluated in heterozygous (rnu/+) normal and homozygous (rnu/rnu) congenitally athymic "nude" Rowett rats. Animals of both types were infected, or immunized and infected, with mutans streptococci (Streptococcus sobrinus strain 6715). The mean numbers of S. sobrinus cells recovered from the nude rats were higher than those from comparable (immune/nonimmune) normal rats in 10 of 12 possible comparisons. Also, S. sobrinus constituted a greater percentage of the total streptococci in the nude rats compared with normal animals (6 of 6 possible comparisons). Antibody to S. sobrinus whole cells or to S. sobrinus glucosyltransferase from nude rats in serum or in saliva was significantly lower (or absent) than that of comparable normal rats. This was seen after infection, but was most pronounced after immunization (and infection). Dental caries was also significantly elevated in the congenitally athymic animals. Immunologic deficiency of congenitally athymic rats can lead to a greater infection level with mutans streptococci and increased dental caries.

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Citations

Jan 2, 2004·Journal of Bacteriology·Isabel Veiga-MaltaArnaldo Videira
Dec 18, 2003·Cellular Microbiology·Isabel Veiga-MaltaPaula Ferreira
Jul 27, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ildikó TarIldikó J Márton
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D J Smith
May 1, 1993·Journal of Dental Research·J M TanzerE D Eanes
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaozhe HanMartin A Taubman
Mar 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hanna M MiettinenMatti Viluksela
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·H Marcotte, M C Lavoie

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