Dental caries susceptibility in mice is closely linked to the H-2 region on chromosome 17

Caries Research
N SuzukiY Kurihara

Abstract

The generation of dental caries in humans is thought to be regulated by many intrinsic and social factors. In this study, we examined the effect of MHC on susceptibility to dental caries in mice. The mean carious score of BALB.K/Ola, a H-2 congenic strain in which the H-2 region derived from C3H/HeJ (H-2(k/k)) is introduced into BALB/cJ (H-2(d/d)), was markedly reduced as compared with that of its recipient strain (BALB/cJ). Mating experiments confirmed a strong genetic linkage between H-2 haplotype and caries susceptibility. These results demonstrate that one of the genetic factors of the susceptibility in the mouse is mapped within the H-2 region. This finding of a host genetic factor influencing the generation of dental caries will help in developing clinical preventive strategies.

Citations

May 10, 2013·Human Genetics·Jessica Briseño-RuizAlexandre R Vieira
Feb 1, 2013·Caries Research·T ShimizuA R Vieira
Jan 9, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Patricia M CorbyBruce J Paster
Jan 18, 2013·Brazilian Oral Research·Alexandre Rezende Vieira
Feb 13, 2001·Oral Microbiology and Immunology·M L WallengrenU Johnson
Sep 24, 2014·Archives of Oral Biology·Masumi OhtaYoshinobu Asada
Feb 3, 2015·Chemical Research in Toxicology·Jing YeWeiping Liu
Feb 22, 2005·Oral Microbiology and Immunology·M L L WallengrenJ Nordberg
Sep 18, 2010·Oral Diseases·R I WerneckP C Trevilatto
Dec 22, 1999·The Journal of the American Dental Association·H C Slavkin
Oct 2, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Betsy FoxmanMary Marazita
Oct 28, 2005·Caries Research·D J CulpR Faustoferri
Aug 30, 2013·Environmental Science & Technology·Juying LiZhong Li
Aug 22, 2012·Caries Research·N ValariniR C Poli-Frederico
Apr 25, 2008·Journal of Dental Research·A R VieiraT Goldstein-McHenry
Mar 12, 2004·Clinical and Diagnostic Laboratory Immunology·Mohammad Abdus SalamHidenobu Senpuku
Dec 6, 2020·Applied and Environmental Microbiology·David J CulpRobert A Burne
Oct 14, 2014·The Journal of Contemporary Dental Practice·Leonardo Santos AntunesErika Calvano Küchler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.