Dental Infection of Porphyromonas gingivalis Induces Preterm Birth in Mice

PloS One
Min AoTakashi Takata

Abstract

Epidemiological studies have revealed a link between dental infection and preterm birth or low birth weight (PTB/LBW), however, the underlying mechanisms remain unclear. Progress in understanding the associated mechanisms has been limited in part by lack of an animal model for chronic infection-induced PTB/LBW, mimicking pregnancy under conditions of periodontitis. We aimed to establish a mouse model of chronic periodontitis in order to investigate the link between periodontitis and PTB/LBW. To establish chronic inflammation beginning with dental infection, we surgically opened mouse (female, 8 weeks old) 1st molar pulp chambers and directly infected with w83 strain Porphyromonas gingivalis (P.g.), a keystone periodontal pathogen. Mating was initiated at 6 wks post-infection, by which time dental granuloma tissue had developed and live P.g. was cultured from extracted tooth root, which serves as a persistent source of P.g. The gestational day (gd) and birth weight were recorded during for P.g.-infected and control mice, and serum and placental tissues were collected at gd 15 to evaluate the systemic and local conditions during pregnancy. Dental infection with P.g. significantly increased circulating TNF-α (2.5-fold), IL-17 (2-f...Continue Reading

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Citations

Jan 2, 2018·Journal of Oral Microbiology·Leticia ReyesMary Brown
Aug 11, 2018·The Journal of Obstetrics and Gynaecology Research·Shihoko Komine-AizawaSatoshi Hayakawa
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Methods Mentioned

BETA
sedation
PCR
SGA

Software Mentioned

GraphPad Prism
Anaeropack

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