Dental management of patient with dual antiplatelet therapy: a meta-analysis

Clinical Oral Investigations
Lin LiJian Zhang

Abstract

It is more common to need dual antiplatelet therapy (DAPT) for patients who had recently inserted coronary artery stent. However, the postoperative bleeding risk of patients in DAPT could significantly increase. The dental management of patients with antithrombotic therapy has always been a controversial problem. Focusing on this issue, this review discussed the available evidence to provide optimal strategy for patients taking dual antiplatelet agents in the dental setting. We searched the PubMed, Embase, ScienceDirect, Web of Science (WOS), Cochrane Library, and China National Knowledge Infrastructure (CNKI) which was performed in May 2018. Relevant articles were included according to our inclusion and exclusion criteria. Meta-analysis was conducted with fixed effects models. Subgroup analysis was used due to different dental surgeries. Our meta-analysis included ten studies (continue DAPT vs. placebo, 535 patients vs.2907 patients). The quantitative results indicated that the risk of postoperative bleeding with continuing DAPT experienced significantly increase (RR = 1.95 95% CI [1.07, 3.54]; p = 0.03). There was no statistically significant difference between the postoperative bleeding rate and different dental surgeries (p...Continue Reading

References

Aug 13, 1998·Archives of Internal Medicine·M J Wahl
Mar 22, 2003·Annals of the Royal College of Surgeons of England·Jonathan Smout, Gerard Stansby
May 28, 2003·Archives of Internal Medicine·David W Todd
Feb 21, 1957·The New England Journal of Medicine·A M ZIFFERA R BERGER
Dec 10, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Glen CarterRic Tocchetti
Apr 14, 2004·Circulation·Allen JeremiasJoseph P Carrozza
Sep 25, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Arvind K SharmaJoseph Lindsay
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Dec 19, 2006·Journal of the American College of Cardiology·Matthias PfistererUNKNOWN BASKET-LATE Investigators
Mar 24, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Doron J AframianDouglas E Peterson
May 8, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·R SaccoP M Mannucci
Dec 18, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yoshinari MorimotoKazuo Minematsu
Jan 16, 2008·Journal of Oral Science·Mariele Pototski, José M Amenábar
Feb 22, 2008·Nature·Nigel Mackman
Apr 21, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Branislav V BajkinSrecko D J Selakovic
Jun 10, 2011·The Canadian Journal of Cardiology·Alan D BellUNKNOWN Canadian Cardiovascular Society
Jul 26, 2011·The American Journal of Cardiology·Theodoros LillisGeorge Giannoglou
Jan 22, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Joel J NapeñasDenise E van Diermen
Oct 15, 2014·The British Journal of Oral & Maxillofacial Surgery·Branislav V BajkinIvana A Bajkin
Dec 3, 2014·Anaesthesia·J J van Veen, M Makris
Jan 13, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Michael J WahlRajesh V Lalla
Jan 30, 2015·BioMed Research International·Alexander GröbeWolfgang Eichhorn
May 1, 2015·The Journal of the American Dental Association·Hesham R OmarEnrico M Camporesi
Aug 15, 2015·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·K George VargheseMohan Sadhanandan
Mar 15, 2016·International Journal of Oral and Maxillofacial Surgery·S-Y LuS-N Lu
Mar 16, 2016·The British Journal of Oral & Maxillofacial Surgery·Mohsen Sadeghi-GhahrodyMohammadhosein Yavarahmadi
Nov 12, 2016·Journal of Maxillofacial and Oral Surgery·Gokkulakrishnan SadhasivamP L Vasundhar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.