Dental Mesenchymal Stem Cell-Based Translational Regenerative Dentistry: From Artificial to Biological Replacement

Frontiers in Bioengineering and Biotechnology
Mona K Marei, Rania M El Backly

Abstract

Dentistry is a continuously changing field that has witnessed much advancement in the past century. Prosthodontics is that branch of dentistry that deals with replacing missing teeth using either fixed or removable appliances in an attempt to simulate natural tooth function. Although such "replacement therapies" appear to be easy and economic they fall short of ever coming close to their natural counterparts. Complications that arise often lead to failures and frequent repairs of such devices which seldom allow true physiological function of dental and oral-maxillofacial tissues. Such factors can critically affect the quality of life of an individual. The market for dental implants is continuously growing with huge economic revenues. Unfortunately, such treatments are again associated with frequent problems such as peri-implantitis resulting in an eventual loss or replacement of implants. This is particularly influential for patients having co-morbid diseases such as diabetes or osteoporosis and in association with smoking and other conditions that undoubtedly affect the final treatment outcome. The advent of tissue engineering and regenerative medicine therapies along with the enormous strides taken in their associated interdi...Continue Reading

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Citations

Jun 28, 2020·Tissue Engineering and Regenerative Medicine·Hua-Lian CaoPill-Hoon Choung
Oct 5, 2019·International Journal of Molecular Sciences·Teerawat SukpaitaRuchanee Salingcarnboriboon Ampornaramveth
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Katiúcia Batista Silva PaivaAriadne Letra
Jun 7, 2019·Molecular Biology Reports·Youdi HeXiao-Xia Jiang
Nov 16, 2021·Stem Cell Research & Therapy·Rasha H Al-SerwiGehan El-Akabawy

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Methods Mentioned

BETA
targeted mutations
biopsy

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