Dental Pulp Stem Cell-Derived Conditioned Medium: An Attractive Alternative for Regenerative Therapy

Tissue Engineering. Part B, Reviews
Charlène KichenbrandVanessa Moby

Abstract

Mesenchymal stem cells (MSC) have a lot of potential in regenerative medicine, and MSC-based therapies are currently explored in numerous research fields. Among these cells, deciduous or permanent dental pulp-MSC represent a promising option in tissue engineering. This expectation is based on their capacity to self-renew, to repair various damaged tissues and organs due to their multipotency, as well as their ability to modulate immune system. They present other advantages such as the harvesting by a simple, painless, and noninvasive procedure and the absence of ethical considerations. The role played by these cells in the reparative process is mainly attributed to paracrine mechanisms mediated by their secreted factors, namely the secretome. The secreted factors can be found in the cell culture medium, called conditioned medium (CM). Moreover, CM presents many advantages compared with cells such as possible use in allogeneic therapies. This minireview aims at investigating the therapeutic use of dental pulp MSC-derived CM to develop cell-free therapies. The analysis of the available literature illustrates its massive panel of potential applications: mainly reduction of inflammation, promotion of angiogenesis and neurogenesis, ...Continue Reading

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Citations

Jan 2, 2019·Bioengineering·Andrea da Fonseca Ferreira, Dawidson Assis Gomes
Sep 3, 2020·Tissue Engineering. Part B, Reviews·Jeremie D OliverRena N D'Souza
Apr 17, 2019·International Journal of Molecular Sciences·Georgy SagaradzeAnastasia Efimenko
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Dec 3, 2020·International Journal of Molecular Sciences·Mahmoud MonaSeunghee Cha
Jan 20, 2021·Neurochemistry International·Batoul ChouaibOlivier Romieu
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Apr 9, 2021·Stem Cell Reviews and Reports·Vincenzo MatteiSimona Delle Monache
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Apr 20, 2021·Frontiers in Cell and Developmental Biology·Guoyang ZhouLin Wang
May 6, 2021·International Journal of Molecular Sciences·Yung-Li WangHui-Wen Chiu
May 7, 2021·Stem Cells International·Dina RadyKarim M Fawzy El-Sayed
Sep 22, 2020·Bioactive Materials·Lu ChenXiaoming Sun
Aug 20, 2021·Tissue Engineering. Part B, Reviews·Bihang ZhangKotaro Yoshimura
Aug 28, 2021·Experimental and Therapeutic Medicine·Qimei GongJunqi Ling
Aug 3, 2021·Cell Regeneration·Nicole Andréa Corbellini HenckesElizabeth Obino Cirne-Lima

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Software Mentioned

BMSC
SHED
CM

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