Dental Stem Cells in Bone Tissue Engineering: Current Overview and Challenges

Advances in Experimental Medicine and Biology
Pinar ErcalGamze Torun Kose

Abstract

The treatment of bone that is impaired due to disease, trauma or tumor resection creates a challenge for both clinicians and researchers. Critical size bone defects are conventionally treated with autografts which are associated with risks such as donor site morbidity and limitations like donor shortage. Bone tissue engineering has become a promising area for the management of critical size bone defects by the employment of biocompatible materials and the discovery of novel stem cell sources. Mesenchymal stem cells (MSCs) can be isolated with ease from various dental tissues including dental pulp stem cells, stem cells from apical papilla, dental follicle stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, gingival stem cells and tooth germ derived stem cells. Outcomes of dental MSC mediated bone tissue engineering is explored in various in vivo and in vitro preclinical studies. However, there are still obscurities regarding the mechanisms underlying in MSC mediated bone regeneration and challenges in applications of dental stem cells. In this review, we summarized dental stem cell sources and their characterizations, along with currently used biomaterials for cell delivery and future ...Continue Reading

Citations

Sep 27, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Frank A Schildberg, Vera S Donnenberg
Jul 18, 2019·Stem Cells Translational Medicine·Ilenia MastroliaMassimo Dominici
Aug 23, 2019·Journal of Molecular Histology·Fuping ZhangShaojie Yu
Apr 2, 2020·International Journal of Molecular Sciences·El-Mustapha HaddoutiFrank A Schildberg
Oct 13, 2018·World Journal of Stem Cells·Mohammed E Grawish
Oct 23, 2019·Stem Cells International·Tao ZhouXin Zhou
Oct 3, 2020·Bioactive Materials·Fengqing ShangYan Jin
Jul 2, 2021·International Journal of Oral Science·Sevda Pouraghaei SevariAlireza Moshaverinia
Oct 12, 2021·Cell Transplantation·Xiaoshuang ZhangHongwu Du

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