Dentate gyrus granule cell firing patterns can induce mossy fiber long-term potentiation in vitro.

Hippocampus
Rajen MistryJ Mellor

Abstract

Hippocampal granule cells transmit information about behaviorally-relevant stimuli to CA3 pyramidal cells via mossy fiber synapses. These synapses express a form of long-term potentiation (mfLTP) that is non-Hebbian and does not require NMDA receptors. mfLTP is thought to be induced and expressed presynaptically, hence, the major determinant of whether mfLTP occurs is activity in the granule cells. However, it remains unclear whether mfLTP can be induced by activity patterns that granule cells exhibit in vivo, and-if so-what context generates these patterns. To address these issues, we examined granule cell activity from in vivo recordings from rats during performance of a delayed nonmatch-to-sample (DNMS) task and found that granule cells exhibit a wide range of spike patterns. In vitro slice experiments in mice demonstrated that some, but not all, of these patterns of activity could induce mfLTP. By further defining the activity thresholds for mfLTP in hippocampal slices, we found that mfLTP can only be induced by spike patterns that fire in high frequency bursts with a low average firing frequency. Using this information, we then screened for suprathreshold bursts of activity during the DNMS task. In a subset of cells, supra...Continue Reading

References

Dec 1, 1992·Journal of Neuroscience Methods·C BianchiC Tomasini
Jul 1, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Marr
Apr 1, 1993·Hippocampus·M W Jung, B L McNaughton
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A SalinR A Nicoll
Mar 21, 1998·Science·G MaccaferriC J McBain
Jun 28, 2000·Neuroscience·D A HenzeG Barrionuevo
Feb 15, 2001·Nature Neuroscience·J Mellor, R A Nicoll
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Jun 1, 2002·Science·Kazu NakazawaSusumu Tonegawa
Jul 16, 2002·Nature Neuroscience·Darrell A HenzeGyörgy Buzsáki
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger
May 6, 2005·Journal of Neurophysiology·M FrerkingU Stäubli
Nov 2, 2005·Nature Reviews. Neuroscience·Roger A Nicoll, Dietmar Schmitz
Jun 20, 2006·Progress in Neurobiology·Edmund T Rolls, Raymond P Kesner
Jun 28, 2006·Pflügers Archiv : European journal of physiology·Josef BischofbergerPeter Jonas
Feb 17, 2007·Science·Jill K LeutgebEdvard I Moser
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ayumu TashiroFred H Gage
Nov 17, 2007·Learning & Memory·Edmund T Rolls
Apr 9, 2008·Progress in Brain Research·Chris J McBain
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming ZhangHongbing Wang
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jens Klausnitzer, Denise Manahan-Vaughan
Jul 16, 2008·Nature Neuroscience·Nicolas ToniAlejandro F Schinder

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Citations

Dec 8, 2011·Cold Spring Harbor Perspectives in Biology·Pablo E Castillo
May 24, 2014·Nature Communications·Ricardo S ScottDmitri A Rusakov
Nov 20, 2015·Frontiers in Cellular Neuroscience·Grzegorz Wiera, Jerzy W Mozrzymas
Apr 20, 2014·Brain Structure & Function·Cornelia J GeertsAlexander J A Groffen
Aug 8, 2015·PLoS Computational Biology·Murat AlpFrancis A Cucinotta
Nov 2, 2016·Frontiers in Synaptic Neuroscience·Luke Y PrinceJack R Mellor
Mar 3, 2017·Nature Reviews. Neuroscience·Nelson RebolaChristophe Mulle
Apr 23, 2019·PLoS Computational Biology·Antoine D MadarMathew V Jones
May 29, 2018·Scientific Reports·Yihui CuiLaurent Venance

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