Dentate gyrus supports slope recognition memory, shades of grey-context pattern separation and recognition memory, and CA3 supports pattern completion for object memory

Neurobiology of Learning and Memory
Raymond P KesnerNick D Musso

Abstract

In order to examine the role of the dorsal dentate gyrus (dDG) in slope (vertical space) recognition and possible pattern separation, various slope (vertical space) degrees were used in a novel exploratory paradigm to measure novelty detection for changes in slope (vertical space) recognition memory and slope memory pattern separation in Experiment 1. The results of the experiment indicate that control rats displayed a slope recognition memory function with a pattern separation process for slope memory that is dependent upon the magnitude of change in slope between study and test phases. In contrast, the dDG lesioned rats displayed an impairment in slope recognition memory, though because there was no significant interaction between the two groups and slope memory, a reliable pattern separation impairment for slope could not be firmly established in the DG lesioned rats. In Experiment 2, in order to determine whether, the dDG plays a role in shades of grey spatial context recognition and possible pattern separation, shades of grey were used in a novel exploratory paradigm to measure novelty detection for changes in the shades of grey context environment. The results of the experiment indicate that control rats displayed a shade...Continue Reading

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Jul 25, 2013·Neurobiology of Learning and Memory·Richard L Dees, Raymond P Kesner

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Citations

Feb 14, 2016·Neurobiology of Learning and Memory·Edmund T Rolls, Raymond P Kesner
Sep 27, 2016·Current Biology : CB·Stevenson BakerR Shayna Rosenbaum
Apr 20, 2017·Hippocampus·Catherine A ThornJeremy R Edgerton
Jul 18, 2019·Brain and Behavior·Yan-Wei ShiXue-Ling Ou
Mar 29, 2019·Scientific Reports·Antoine D MadarMathew V Jones
Sep 16, 2017·Frontiers in Aging Neuroscience·Mona BuhusiCatalin V Buhusi
Oct 6, 2020·Addiction Biology·Patrick A RandallJoyce Besheer
Mar 1, 2018·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Nina Vanessa KraguljacAdrienne Carol Lahti

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