Dec 7, 2013

Dentin biomodification: strategies, renewable resources and clinical applications

Dental Materials : Official Publication of the Academy of Dental Materials
Ana Karina Bedran-RussoAriene Leme


The biomodification of dentin is a biomimetic approach, mediated by bioactive agents, to enhance and reinforce the dentin by locally altering the biochemistry and biomechanical properties. This review provides an overview of key dentin matrix components, targeting effects of biomodification strategies, the chemistry of renewable natural sources, and current research on their potential clinical applications. The PubMed database and collected literature were used as a resource for peer-reviewed articles to highlight the topics of dentin hierarchical structure, biomodification agents, and laboratorial investigations of their clinical applications. In addition, new data is presented on laboratorial methods for the standardization of proanthocyanidin-rich preparations as a renewable source of plant-derived biomodification agents. Biomodification agents can be categorized as physical methods and chemical agents. Synthetic and naturally occurring chemical strategies present distinctive mechanism of interaction with the tissue. Initially thought to be driven only by inter- or intra-molecular collagen induced non-enzymatic cross-linking, multiple interactions with other dentin components are fundamental for the long-term biomechanics an...Continue Reading

  • References115
  • Citations36


  • References115
  • Citations36


Mentioned in this Paper

Covalent Interaction
Cranberry preparation
Cacao Plant
Green Tea Extract
Dental Pulp

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