Dentin caries zones: mineral, structure, and properties.

Journal of Dental Research
M K PugachG W Marshall

Abstract

Caries Detector staining reveals 4 zones in dentin containing caries lesions, but characteristics of each zone are not well-defined. We therefore investigated the physical and microstructural properties of carious dentin in the 4 different zones to determine important differences revealed by Caries Detector staining. Six arrested dentin caries lesions and 2 normal controls were Caries-Detector-stained, each zone (pink, light pink, transparent, apparently normal) being analyzed by atomic force microscopy (AFM) imaging for microstructure, by AFM nano-indentation for mechanical properties, and by transverse digital microradiography (TMR) for mineral content. Microstructure changes, and nanomechanical properties and mineral content significantly decreased across zones. Hydrated elastic modulus and mineral content from normal dentin to pink Caries-Detector-stained dentin ranged from 19.5 [10.6-25.3] GPa to 1.6 [0.0-5.0] GPa and from 42.9 [39.8-44.6] vol% to 12.4 [9.1-14.2] vol%, respectively. Even the most demineralized pink zone contained considerable residual mineral.

References

Oct 1, 1977·Journal of Dental Research·Y KubokiT Fusayama
Sep 1, 1975·Journal of Dental Research·K Ogushi, T Fusayama
Apr 1, 1992·Journal of Dental Research·J Arends, J J ten Bosch
Jul 1, 1985·The Journal of Prosthetic Dentistry·M H AndersonG T Charbeneau
Jan 20, 1985·Journal of Molecular Biology·L C BonarH A Mook
May 1, 1972·Journal of Dental Research·T Fusayama, S Terachima
Jun 1, 1983·Journal of Dental Research·Y KubokiT Fusayama
Sep 1, 1994·Journal of Dental Research·J M WhiteG W Marshall
Nov 1, 1993·Archives of Oral Biology·J H KinneyS J Marshall
Jan 1, 1996·Archives of Oral Biology·J H KinneyT P Weihs
Oct 24, 2001·Journal of Dental Research·G W MarshallS J Marshall
Jun 8, 2002·Journal of Biomechanics·Stefan HabelitzSally J Marshall
Jun 6, 2003·European Journal of Oral Sciences·Lei ZhengGrayson W Marshall
Sep 27, 2003·Dental Materials : Official Publication of the Academy of Dental Materials·Sofia S A OliveiraGrayson W Marshall
Oct 28, 2003·Methods in Molecular Biology·Grayson W MarshallJohn H Kinney
Jul 11, 2006·Journal of Biomedical Optics·Cynthia L DarlingDaniel Fried

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Citations

Aug 10, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Li-Na NiuFranklin R Tay
Feb 12, 2009·Caries Research·L E BertassoniG W Marshall
Jun 1, 2010·Journal of Dental Research·E BrescianiM C Peters
Oct 4, 2012·Journal of Applied Oral Science : Revista FOB·Fernanda Brandão MollicaMaria Nadir Gasparoto Mancini
Aug 25, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Zhongpu ZhangMichael V Swain
May 4, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Heonjune RyouDwayne Arola
Jan 15, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Kuniko SaekiSally J Marshall
Feb 22, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Heonjune RyouDwayne Arola
Feb 22, 2011·Journal of Dentistry·Aline A NevesBart Van Meerbeek
Dec 17, 2009·Dental Materials : Official Publication of the Academy of Dental Materials·Jorge Perdigão
Oct 2, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Asbjørn Jokstad
Nov 24, 2011·Lasers in Surgery and Medicine·Michal StaninecDaniel Fried
Jan 8, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Gerardo José JovesJunji Tagami
Apr 28, 2012·Journal of Biomechanics·Luiz Eduardo Bertassoni, Michael Vincent Swain
Mar 30, 2013·Dental Materials Journal·Sachiko UtakaJunji Tagami
Sep 29, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Hans DeyhleBert Müller
Apr 10, 2015·PloS One·Sabra I DjomehriSunita P Ho
Jan 30, 2014·Brazilian Dental Journal·Larissa Ferreira PachecoRegina Maria Puppin-Rontani
Oct 28, 2011·Brazilian Oral Research·Cynthia Soares de AzevedoAdriana Bona Matos
Dec 21, 2013·Journal of Dental Research·C M P VidalM R Carrilho
Dec 1, 2017·Clinical Oral Investigations·Renata Costa de MoraisFernanda de Carvalho Panzeri Pires-de-Souza
Nov 17, 2016·Restorative Dentistry & Endodontics·Young-Hye SungJuhea Chang
Jun 10, 2020·International Journal of Paediatric Dentistry·Carolina LochLyndie A Foster Page
Feb 2, 2013·Dental Materials Journal·Gerardo José JovesJunji Tagami
Apr 14, 2020·Journal of Cellular and Molecular Medicine·Lisanne GrünherzArndt Friedrich Schilling
Jul 7, 2020·Dental Materials Journal·Hamid NurrohmanGrayson W Marshall
Oct 10, 2015·Dentistry Journal·Hans DeyhleBert Müller
Dec 29, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Dominique WeimannHajar Razi

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Methods Mentioned

BETA
atomic force microscopy
AFM

Software Mentioned

Nanoscope
AFM

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