Dentin matrix protein 1 (DMP1) expression in developing human teeth

Brazilian Dental Journal
Elizabeth Ferreira MartinezVera Cavalcanti de Araújo

Abstract

Dentin matrix protein 1 (DMP1) is an acidic phosphoprotein that plays an important role in mineralized tissue formation by initiation of nucleation and modulation of mineral phase morphology. The purpose of the present study was to examine the immunoexpression of DMP1 in tooth germs of 7 human fetuses at different gestational ages (14, 16, 19, 20, 21, 23 and 24 weeks) comparing with completed tooth formation erupted teeth. The results showed the presence of DMP1 in the dental lamina, as well as in the cells of the external epithelium, stellate reticulum and stratum intermedium of the enamel organ. However, in the internal dental epithelium, cervical loop region and dental papilla some cells have not labeled for DMP1. In the crown stage, DMP1 was expressed in the ameloblast and odontoblast layer, as well as in the dentinal tubules of coronal dentin near the odontoblast area. Erupted teeth with complete tooth formation exhibited immunolabeling for DMP1 only in the dentinal tubules mainly close to the dental pulp. No staining was observed in the enamel, predentin or dental pulp matrix. DMP1 is present in all developing dental structures (dental lamina, enamel organ, dental papilla) presenting few immunoexpression variations, with ...Continue Reading

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Citations

Dec 22, 2012·International Journal of Oral Science·Afsaneh RangianiJian-Quan Feng
Dec 14, 2011·Journal of Endodontics·Ashraf Abd-ElmeguidHarissios Vliagoftis
Mar 23, 2012·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·T SawadaT Yanagisawa
Feb 14, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Natalino Lourenço NetoThais M Oliveira
Feb 1, 2019·Journal of Dental Research·F ChmilewskyA George
Jul 18, 2018·Frontiers in Physiology·Sali Al-AnsariFrederik R Rozema
Mar 27, 2019·Clinical Oral Investigations·Ana Cláudia Garcia RosaVera Cavalcanti de Araújo

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