Feb 17, 2010

Dentinogenesis and Dentin Sialophosphoprotein (DSPP)

Journal of Oral Biosciences
Yasuo Yamakoshi


Dentin sialophosphoprotein (DSPP) is critical for proper mineralization of tooth dentin, and understanding its structure and function should yield important insights into how dentin biomineralization is controlled. During the recent six years, I have focused on characterizing DSPP-derived proteins isolated from developing porcine teeth. Porcine DSPP is expressed and secreted by odontoblasts and is processed by BMP-1, MMP-20 and MMP-2 into three main parts: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We have learned that DSP is a proteoglycan that forms covalent dimers, DGP is a phosphorylated glycoprotein, and DPP is a highly phosphorylated intrinsically disordered protein that shows extensive length polymorphisms due to the genetic heterogeneity of its coding region.

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  • Citations11


Mentioned in this Paper

Covalent Interaction
Matrix Metalloproteinase 2
MMP-2 Activity
Pathologic Mineralization
DSPP gene

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