PMID: 6971442Dec 1, 1980Paper

Deoxycorticosterone biosynthesis in human kidney: potential for formation of a potent mineralocorticosteroid in its site of action

Proceedings of the National Academy of Sciences of the United States of America
C A WinkelP C MacDonald

Abstract

The extra-adrenal formation of deoxycorticosterone (DOC) from plasma progesterone has been demonstrated in humans. In those studies it was shown that in some persons the volume of plasma cleared of progesterone by DOC formation was great, namely, 75 liter/24 hr. Because steroid 231-hydroxylase activity [steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating), EC 1.14.99.10] could not be demonstrated in homogenates or microsome-enriched preparations of human lung or liver tissue, we speculated that the 21-hydroxylation of plasma progesterone might take place in the kidney. Employing whole tissue homogenates and microsome-enriched preparations of human kidney tissue, we demonstrated the formation of [3H]DOC from kidney tissue, we demonstrated the formation of [3H]DOC from [3H]progesterone. The rate of formation of DOC from progesterone in microsomal preparations from kidney tissues of adult humans varied from 0 to 803 pmol per mg of microsomal protein per hr. The value computed for the apparent Km of the enzyme for progesterone was 0.140 microM. On the basis of these findings, we conclude that steroid 21-hydroxylase activity is present in human kidney tissue and that the kidney may be an importa...Continue Reading

References

Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·M Schöneshöfer, G G Wagner
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Citations

Sep 15, 1982·Klinische Wochenschrift·K HierholzerI Witt
Aug 1, 1983·Journal of Steroid Biochemistry·A GueramiP C MacDonald
Oct 1, 1983·Journal of Steroid Biochemistry·M L Casey, P C MacDonald
Jul 1, 1988·Journal of Steroid Biochemistry·K NahoulR Scholler
Nov 1, 1989·Journal of Steroid Biochemistry·G T GriffingJ C Melby
Feb 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C Bijault, L Dehennin
Feb 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·S LajicM Holst
Feb 13, 2001·Molecular and Cellular Endocrinology·M QuinklerS Diederich
Aug 1, 1989·Baillière's Clinical Endocrinology and Metabolism·J M Davison, M D Lindheimer
Sep 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·D RogoffA Slominski
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P C WhiteB Dupont
Aug 1, 1982·The Journal of Clinical Investigation·M L Casey, P C MacDonald
Jul 1, 1985·American Journal of Obstetrics and Gynecology·M K McLaughlinJ G Farnham
Feb 13, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Berthold LöhrkeTorsten Viergutz
Jan 1, 1985·Annals of the New York Academy of Sciences·P C WhiteB Dupont
Jan 1, 1987·Archives of Biochemistry and Biophysics·M J FinlaysonE F Johnson
Nov 16, 2010·Molecular and Cellular Endocrinology·Melina A PagottoLiliana Alicia Monasterolo
May 20, 1986·Biochemistry·M E JohnM R Waterman
Jun 19, 2017·Steroids·David J Morris, Jason M Ridlon
Jul 1, 1986·The Journal of Urology·D B KarpfG D Braunstein
Jan 1, 1987·Pflügers Archiv : European journal of physiology·N KobayashiK Hierholzer
Jan 1, 1989·Endocrine Research·S Narasimhulu
Jan 18, 2003·Endocrine Research·M Quinkler, S Diederich

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