Deoxycorticosterone-secreting adrenocortical carcinoma

Endocrine Pathology
Akihiro YamamotoHironobu Sasano

Abstract

A case of DOC-secreting adrenocortical carcinoma in a 66-year-old man is reported. He had hypertension, hypokalemia, suppressed PRA, and excessive serum levels of DOC. His serum aldosterone level was normal. The resected adrenal mass weighed 230 g. Histologically, the tumor was mainly composed of compact cells associated with necrosis and atypical mitoses. Invasion of venous structure, sinusoids, and capsule was also present. Immunohistochemically, P450 C21 (21 -hydroxylase) was positive in many tumor cells, and P450 C17(17 α-hydroxylase) was intensely positive in a relatively small number of tumor cells. The patient died 9 months after operation due to rupture of metastatic liver tumor.Endocr Pathol 4:165-168, 1993.

References

Nov 1, 1987·The Journal of Clinical Endocrinology and Metabolism·I IronyH Rubinoff
Feb 1, 1987·Endocrinologia Japonica·K MakinoK Miura
Apr 6, 1974·British Medical Journal·J D Powell-JacksonA Wilson
Mar 1, 1984·The American Journal of Surgical Pathology·L M Weiss

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