Deoxycytidylate and deoxyguanylate kinase activity in pneumococci after exposure to known polyribonucleotides

Science
W FirsheinM Sease

Abstract

Polycytidylic acid and to a lesser extent polyadenylic acid enhance the activity of deoxycytidylate and deoxyguanylate kinases in resting cell suspensions of encapsulated pneumococci. The active intracellular materials appear to be oligomers of A and C, respectively. The stimulation of the kinase activities is amino-acid dependent and can be abolished by the addition of chloramphenicol. The addition of all eight naturally occurring deoxyribonucleosides and deoxyribonucleotides to cell suspensions containing the homopolymers leads to a selective enhancement of DNA synthesis.

References

Sep 1, 1969·Biulleten' eksperimental'noĭ biologii i meditsiny·B B FuksA L Shnaper
Jan 1, 1974·Advances in Enzyme Regulation·D S CoffeyW D Heston
Sep 1, 1968·Japanese Journal of Microbiology·T FukadaT Shima
Mar 5, 1971·Biochemical and Biophysical Research Communications·J G CoryA J Girgenti

Related Concepts

Protoplasm
Deoxyribonucleosides
DNA Biosynthetic Process
DNA Replication
Phosphotransferases
Deoxyribonucleotides
Polyribonucleotides
Interphase Cell
DNA Chemical Synthesis
Chloramphenicol Measurement

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