PMID: 6540615Jul 30, 1984Paper

Deoxyglucose uptake and choline acetyltransferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis

Brain Research
M V Lamarca, H C Fibiger

Abstract

The uptake of [3H]2-deoxyglucose (2-DG) into various brain regions of rats with unilateral or bilateral lesions of the nucleus basalis magnocellularis (nBM) was measured. The activity of choline acetyltransferase (ChAT) in these brain regions was also determined. Lesions of the nBM caused a significant decrease in cortical ChAT activity but had no effect on 2-DG accumulation. Pentobarbital treatment reduced 2-DG accumulation in all brain areas examined and these reductions were not influenced by the nBM lesions. The results indicate that a decrease in the cholinergic innervation of the cortex does not influence cortical glucose utilization. It appears unlikely, therefore, that the reported decrease in cortical glucose utilization in Alzheimer's disease is related to degeneration of the nBM-cortical cholinergic projection.

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Citations

Jan 1, 1995·Pharmacology & Therapeutics·F Dauphin, E T MacKenzie
Jan 1, 1985·Neurobiology of Aging·R J BoegmanS K Ludwin
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·G L Wenk, D S Olton
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Jan 1, 1991·Neuroscience and Biobehavioral Reviews·A J DekkerL J Thal
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GaleaC Estrada
Sep 1, 1986·Stroke; a Journal of Cerebral Circulation·D M Feeney, J C Baron
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G MehlhornR Schliebs
Aug 1, 1986·The International Journal of Neuroscience·J KesslerG Sigg
Jul 1, 1990·The Journal of Comparative Neurology·S L JulianoD Eslin

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