Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel

Toxicological Sciences : an Official Journal of the Society of Toxicology
Hui-Ren Zhou, James J Pestka

Abstract

Food refusal is a hallmark of exposure of experimental animals to the trichothecene mycotoxin deoxynivalenol (DON), a common foodborne contaminant. Although studies in the mouse suggest that DON suppresses food intake by aberrantly inducing the release of satiety hormones from enteroendocrine cells (EECs) found in the gut epithelium, the underlying mechanisms for this effect are not understood. To address this gap, we employed the murine neuroendocrine tumor STC-1 cell line, a widely used EEC model, to test the hypothesis that DON-induced hormone exocytosis is mediated by G protein-coupled receptor (GPCR)-mediated Ca(2+) signaling. The results indicate for the first time that DON elicits Ca(2)-dependent secretion of cholecystokinin (CCK) and glucagon-like peptide-1(7-36) amide (GLP-1), hormones that regulate food intake and energy homeostasis and that are products of 2 critical EEC populations--I cells of the small intestine and L cells of the large intestine, respectively. Furthermore, these effects were mediated by the GPCR Ca(2+)-sensing receptor (CaSR) and involved the following serial events: (1)PLC-mediated activation of the IP3 receptor and mobilization of intracellular Ca(2+) stores, (2) activation of transient receptor...Continue Reading

References

Jun 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hui-Ren ZhouJames J Pestka
Mar 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Owais B ChaudhriStephen R Bloom
Apr 29, 2006·Obesity·Michael W Schwartz
Jun 14, 2006·Physiology & Behavior·Nicholas P Hays, Susan B Roberts
Jun 5, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bernadette VidemannSylvaine Lecoeur
Oct 25, 2008·Digestion·Hongjie ZhangLin Lin
Dec 17, 2008·Endocrinology·Diana L WilliamsMichael W Schwartz
Apr 7, 2009·Regulatory Peptides·Graham J Dockray
Jul 1, 2009·Molecular and Cellular Endocrinology·Efthimia Karra, Rachel L Batterham
Oct 24, 2009·Gene Expression Patterns : GEP·Susanne StaafPatrik Ernfors
Oct 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fiore CattaruzzaNigel W Bunnett
Oct 13, 2010·Molecular Nutrition & Food Research·Maartje C P GeraedtsWim H M Saris
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alice P LiouStephen A Wank
Aug 30, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Clémence GirardetJean-Denis Troadec
Oct 15, 2011·American Journal of Physiology. Cell Physiology·Bhavik P ShahTimothy A Gilbertson
Jan 12, 2012·British Journal of Pharmacology·E S FernandesJ E Keeble
Jan 18, 2012·Handbook of Experimental Pharmacology·Gwen TolhurstFiona M Gribble
Feb 15, 2012·Advances in Nutrition·Sofia Moran-RamosNimbe Torres
Mar 29, 2012·Advances in Experimental Medicine and Biology·Bandana ChakravartiEdward M Brown
Apr 10, 2012·Cell Metabolism·Frank ReimannFiona M Gribble
Apr 17, 2012·Clinical Biochemistry·Bryan K WardThomas Ratajczak
Jun 1, 2012·Molecular Nutrition & Food Research·Shingo NakajimaHiroshi Hara
Aug 21, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brenna M FlanneryJames J Pestka
Aug 22, 2012·The Proceedings of the Nutrition Society·Fiona M Gribble
Sep 25, 2012·Pflügers Archiv : European journal of physiology·Bernd NiliusGrzegorz Owsianik
May 22, 2013·Current Pharmaceutical Design·Young Hee Choi, Ai-Ming Yu
Jan 3, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Rishil J KathawalaZhe-Sheng Chen

❮ Previous
Next ❯

Citations

Sep 26, 2015·Archives of Toxicology·Alix PierronIsabelle P Oswald
Apr 20, 2016·Toxicon : Official Journal of the International Society on Toxinology·Misa TominagaKazuo Kobayashi-Hattori
Sep 27, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wenda WuJames J Pestka
May 29, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Ruonan LiChunmei Li
Feb 15, 2019·Nature Reviews. Endocrinology·Fiona M Gribble, Frank Reimann
Jun 22, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Hervé RobertIsabelle P Oswald
Nov 2, 2019·Physiological Reviews·Karel TalaveraBernd Nilius
Jul 28, 2019·Animals : an Open Access Journal From MDPI·Jiangyin FengSuqin Hang
Sep 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Lutz Edler
Aug 15, 2019·Cell and Tissue Research·Hongxia WangJohn R Grider
Sep 22, 2020·Journal of Gastroenterology and Hepatology·Paul L R AndrewsGareth J Sanger
Jul 10, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P L R AndrewsJ F Nash

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.