PMID: 6988412Mar 1, 1980Paper

Deoxyribonucleic acid-deficient strains of Candida albicans

Journal of Bacteriology
A F OlaiyaS J Sogin

Abstract

We analyzed a series of germ tube-negative variants isolated from Candida albicans 3153A for deoxyribonucleic acid content. As analyzed by flow microfluorometry, the deoxyribonucleic acid level in these variant strains was 50% of that of the parental strain and equivalent to that of haploid Saccharomyces cerevisiae. This finding was confirmed by comparison of survival rates when exposed to the mutagens ultraviolet light, ethyl methane sulfonate, and methyl methane sulfonate. The diameter of the variant cells as compared to the diameter of the parental 3153A strain showed a relationship similar to that of the diameters of haploid versus diploid S. cerevisiae. These results indicate that those strains may be representative of the imperfect stage of C. albicans.

Citations

Mar 1, 1981·Archives of Microbiology·A SarachekR H Schwarzhoff
Apr 12, 2005·Eukaryotic Cell·Paul R LephartPaul T Magee
Jan 1, 1987·Critical Reviews in Microbiology·W L Whelan

Related Concepts

Candida albicans
DNA, Fungal
Ethyl Methanesulfonate
Haploid Cell
Interphase
Dimethylsulfonate
Fluorescence Spectroscopy
Black Light, Ultraviolet

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