Dependence of achievable plan quality on treatment technique and planning goal refinement: a head-and-neck intensity modulated radiation therapy application

International Journal of Radiation Oncology, Biology, Physics
X Sharon QiJohn Demarco

Abstract

To develop a practical workflow for retrospectively analyzing target and normal tissue dose-volume endpoints for various intensity modulated radiation therapy (IMRT) delivery techniques; to develop technique-specific planning goals to improve plan consistency and quality when feasible. A total of 165 consecutive head-and-neck patients from our patient registry were selected and retrospectively analyzed. All IMRT plans were generated using the same dose-volume guidelines for TomoTherapy (Tomo, Accuray), TrueBeam (TB, Varian) using fixed-field IMRT (TB_IMRT) or RAPIDARC (TB_RAPIDARC), or Siemens Oncor (Siemens_IMRT, Siemens). A MATLAB-based dose-volume extraction and analysis tool was developed to export dosimetric endpoints for each patient. With a fair stratification of patient cohort, the variation of achieved dosimetric endpoints was analyzed among different treatment techniques. Upon identification of statistically significant variations, technique-specific planning goals were derived from dynamically accumulated institutional data. Retrospective analysis showed that although all techniques yielded comparable target coverage, the doses to the critical structures differed. The maximum cord doses were 34.1 ± 2.6, 42.7 ± 2.1, 4...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·UNKNOWN Intensity Modulated Radiation Therapy Collaborative Working Group
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuRupert Schmidt-Ullrich
Dec 17, 2008·Physics in Medicine and Biology·Thomas Bortfeld, Steve Webb
Jun 24, 2009·Medical Physics·X Sharon QiX Allen Li
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Lawrence B MarksJoseph O Deasy
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Kevin L MooreSasa Mutic
Jul 23, 2011·Medical Physics·Vorakarn ChanyavanichJoseph Y Lo
Dec 20, 2011·Seminars in Radiation Oncology·Jean M Moran, Benedick A Fraass
Dec 20, 2011·Seminars in Radiation Oncology·Kevin L MooreSasa Mutic

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Citations

Dec 19, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Sun-Yung BakSteve P Lee
Oct 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·X Sharon QiPatrick Kupelian

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