Dependence of biofilm-forming ability on the antibiotic sensitivity of Pseudomonas aeruginosa clinical strains isolated from patients with chronic osteomyelitis

Klinicheskaia laboratornaia diagnostika
I V ShipitsynaD S Leonchuk

Abstract

Due to the spreading highly resistant strains among clinically significant P. aeruginosa clones, it becomes necessary to prescribe antibiotics not only taking into account the knowledge of sensitivity spectrum of a particular isolate but the data of microorganism biofilm activity as well. To study the dependence of biofilm-forming ability on the sensitivity to antibacterial preparations of P. aeruginosa clinical strains, isolated from patients with chronic osteomyelitis. 36 patients above 18 with chronic osteomyelitis of long tubular bones who were treated in the center of purulent osteology took part in the experiment. Object of the study - material isolated from wounds, fistulas, as well as from inflammatory foci. The sensitivity of isolated microorganisms to 10 antibiotics was analyzed: Piperacillin/Tazobactam, Imipenem, Meropenem, Aztreonam, Amikacin, Ciprofloxacin, Ceftriaxone, Ceftazidime, Cefotaxime, Cefepime. High- and medium-adhesive strains accounted for 86,1 % among P. aeruginosa clinical isolates, obtained from the wounds of patients with chronic osteomyelitis of long tubular bones. Highly adhesive strains are resistant to a wide range of antibacterial preparations used clinically. Penicillins were the most effectiv...Continue Reading

References

Nov 25, 2003·Nature·Thien-Fah MahGeorge A O'Toole
Mar 7, 2014·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Takahiro Shimada, Itaru Matsumura

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Citations

Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen

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