PMID: 5765Feb 1, 1976

Dependence of CSF on plasma bicarbonate during hypocapnia and hypoxemic hypocapnia

Respiration Physiology
D A Pelligrino, J A Dempsey


We have previoulsy shown pH compensation to be similar in CSF and arterial blood during chronic hypoxemic hypocapnia in man and pony, and postulated that the compensatory reduction in CSF [HCO3] was dependent upon corresponding changes in [HCO3]a. We tested this hypothesis in anesthetized, paralyzed dogs by determining the effects of 7 or 14 hours of hypocapnia (PaCO2 20 and 30 mm Hg), hypoxemia (PaO2 30, 38 and 48 mm Hg) and hypocapnic hypoxemia on CSF acid-base status. [hco3]a was either permitted to fall normally or was held near control levels by NaHCO3 infusion. In hypocapnia and hypoxemic hypocapnia, the decrease in [HCO3] and % pH compensation in CSF were less than or equal to that in arterial blood. Most (51-89%) of the compensatory decrease in CSF [HCO3] was prevented by preventing the corresponding reduction in [HCO3]a. This dependence of changes in CSF on plasma [HCO3] required a concurrent decrease in CSF PCO2, but was largely independent of variations in plasma pH. A minor but significant portion of the decrease in CSF [HCO3] was achieved independently of corresponding changes in [HCO3]a. The contribution of this local mechanism to CSF [HCO3] regulation increased with increasing severity of hypocapnia or hypoxemia ...Continue Reading


Dec 1, 1965·Archives internationales de physiologie et de biochimie·P J Van VaerenberghI Leusen
Dec 1, 1974·Respiration Physiology·M A Kelley, H Kazemi
Dec 1, 1973·Respiration Physiology·M C BlayoJ J Pocidalo
Apr 1, 1974·The Journal of Clinical Investigation·J A DempseyG A doPico
Jul 1, 1972·The Journal of Clinical Investigation·F J GennariW B SCHWARTZ
Sep 1, 1971·Acta Physiologica Scandinavica·K Messeter, B K Siesjö
Oct 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·B K Siesjö
Aug 1, 1969·Scandinavian Journal of Clinical and Laboratory Investigation·B K Siesjö, A Kjällquist
Mar 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·J L PannierI Leusen
Dec 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·N A Lassen
Sep 15, 1966·Experientia·B K Siesjö, U Pontén
Apr 1, 1967·The American Journal of Physiology·F Plum, J B Posner
Jan 1, 1964·The Journal of Clinical Investigation·H L BLEICHW B SCHWARTZ


Apr 1, 1982·Pflügers Archiv : European journal of physiology·J WeyneI Leusen
Dec 9, 2003·Journal of Applied Physiology·Neil S Cherniack

Related Concepts

Anion Gap
Carbonic Acid Ions
Carbon Dioxide
Canis familiaris
Hydrogen-Ion Concentration

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.